| 人脐血单个核细胞输注对血管性痴呆大鼠的行为改善作用 |
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| 引用本文： | 王昌铭,孙鸣,向静,王景周,吉国泰,苏长雨.人脐血单个核细胞输注对血管性痴呆大鼠的行为改善作用[J].实用医药杂志(山东),2010,27(4):354-356. |
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| 作者姓名： | 王昌铭 孙鸣 向静 王景周 吉国泰 苏长雨 |
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| 作者单位： | 王昌铭,孙鸣,吉国泰,苏长雨(150医院神经内科,河南洛阳,471031);向静,王景周(第三军医大学大坪医院野战外科研究所神经内科,重庆,400042) |
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| 基金项目： | 重庆市科委科研基金攻关项目 |
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| 摘 要： | 目的观察颈内动脉输注人脐血单个核细胞(human cord blood mononuclear cells,HCMNCs)对血管性痴呆(vascular dementia,VD)大鼠的行为学改善的作用以及对VD大鼠血清脑特异性蛋白神经元特异性烯醇化酶(neuron spcific enolase,NSE)和S-100蛋白的影响。方法大鼠随机分为模型组、治疗组、对照组;各组大鼠又分为2、4、8周3个时相点。以穿梭箱对大鼠行为学进行检测。用ELISA法对大鼠血清中NSE和S-100蛋白进行检测。结果穿梭箱结果显示HCMNCs治疗组大鼠术后各时相点主动回避反应(active avoidance response,AAR)比例均显著高于模型组。治疗组大鼠术后各时相点血清NSE和S-100蛋白含量与模型组有显著性差异,与对照组比较无显著性差异。结论采用HCMNCs治疗对VD大鼠的行为学有一定的改善作用,说明HCMNCs治疗对脑组织细胞有一定的保护作用。
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| 关 键 词： | 脐血单个核细胞 血管性痴呆 Pulsinellis四血管阻断法 颈内动脉 神经元特异性烯醇化酶 S-100蛋白 |
Effect of of intracarotid administration of human cord blood mononuclear cells on the action improvement of vascular dementia rats |
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| WANGCHang-ming%e%%a,SUNMing,XIANGJing,etal.%e%%a.Effect of of intracarotid administration of human cord blood mononuclear cells on the action improvement of vascular dementia rats[J].Practical Journal of Medicine & Pharmacy,2010,27(4):354-356. |
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| Authors: | WANGCHang-ming%e%%a SUNMing XIANGJing etal%e%%a |
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| Institution: | WANG+CHang-ming%e2%91%a0,SUN+Ming,XIANG+Jing,et+al.%e2%91%a0Department+of+Neurology,the+150th+Hospital+of+Chinese+PLA,Luoyang,Henan+471031,China |
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| Abstract: | Objective To investigate the effect of intracarotid administration of human cord blood mononuclear cells(HCMNCs)on active avoidance response(AAR)ratio of vascular dementia rats,and the effect on neuron specific enolase(NSE)and S-100 protein of vascular dementia rats.Method The rats were randomly divided into model group,treatment group and control group.The three groups were observed at the 2nd,4th and 8th week,respectively.Serum samples of rats were taken at 2nd,4th and 8th after operation.NES and S-100 pr... |
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| Keywords: | Human cord blood mononuclear cells Vascular dementia Pulsinellis 4-Vessel occlusion Intracarotid Neuron specific enolase S-100 protein |
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