分服与顿服米非司酮流产的临床效果观察

目的比较相同剂量米非司酮分服与顿服在终止10~14周妊娠的临床效果。方法以2012年1月至2013年1月间在本院住院进行药物流产的患者200例为研究对象,随机分为米非司酮分服组（100例）与米非司酮顿服组（100例）,分服组：口服米非司酮50mg,12h后再服25mg,连服2d,共150mg;顿服组：在第一天直接口服米非司酮150mg。两组都在第3天上午服米索前列醇600μg。服药前后各禁食2h以促进药物吸收。观察两组疗效并随访,通过统计分析比较两组患者在药物流产临床疗效、胚囊排出时间、阴道出血时间、月经复潮时间以及药物不良反应方面的差异。结果分服组与顿服组相比,胚囊排出时间较少且临床疗效较好,差异具有统计学意义（P〈0.05）,其余各方面指标差异均不具有统计学意义（P〉0.05）,两组患者不良反应均轻微,可自行缓解无须特殊处理。结论分服米非司酮与顿服米非司酮在流产效果上相比较,优势明显。

The effect analysis of different medication way in the use of mifepristone for the early pregnancy abortion

Objective To analysis the effect of different medication way in the use of Mifepristone for the early pregnancy abortion . Method 200 pregnant women with the need of early pregnancy abortion were divided into objective group and the control group.The Mifepristone was separately used in the objective group, and the control used Mifepristone just one time every day.The difference of related indicators of pregnancy abortion between the two groups were compared. Results The time of embryo sac discharge of the objective group was shorter than the control group.The pregnancy abortion effect of the objective group was more positive than the control group. Conclusion It would get a satisfactory effect to use separated Mifepristone up to the need.