| 血清IL-6和IL-8在还原型谷胱甘肽治疗肝硬化患者前后的变化 |
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| 引用本文： | 李力,顾晓红. 血清IL-6和IL-8在还原型谷胱甘肽治疗肝硬化患者前后的变化[J]. 实用肝脏病杂志, 2005, 8(5): 274-275 |
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| 作者姓名： | 李力 顾晓红 |
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| 作者单位： | 200090,上海市杨浦区中心医院消化科 |
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| 摘 要： | 目的 探讨肝硬化患者血清白细胞介素6（IL-6）、白细胞介素8（IL-8）水平变化的临床意义。方法 采用ELISA法测定肝硬化患者治疗前后血清IL-6和IL-8水平。结果 36例肝硬化患者血清IL-6、IL-8水平较正常对照组显著增高。采用还原型谷胱甘肽治疗一个月后肝功能恢复者血清IL-6、IL-8水平较治疗前显著降低，而肝功能未恢复者血清IL-6、IL-8水平较治疗前降低不明显。结论 肝功能损伤可能是白细胞介素活性增加的重要原因，细胞因子的水平与肝硬化的形成及预后有关，还原型谷胱甘肽具有一定的治疗作用。
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| 关 键 词： | 肝硬化 白细胞介素6 白细胞介素8 还原型谷胱甘肽 白细胞介素8（IL-8） 血清IL-6 肝硬化患者 治疗前后 IL-8水平 血清白细胞介素 |
| 收稿时间： | 2005-05-23 |
| 修稿时间： | 2005-05-23 |
Study on the relationship between interleukin-6 and interleukin-8 levels and the prognosis in patients with liver cirrhosis |
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| Li li,Gu Xiaohong. Study on the relationship between interleukin-6 and interleukin-8 levels and the prognosis in patients with liver cirrhosis[J]. Journal of Clinical Hepatology, 2005, 8(5): 274-275 |
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| Authors: | Li li Gu Xiaohong |
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| Affiliation: | Department of Gastroenterology , Shanghai Yang Pu Central Hospital, Shanghai 200090, China |
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| Abstract: | Objective To investigate the changes and clinical significanees of interleukin-6 and interleukin-8 on prognosis in patients with liver cirrhosis. Methods The serum levels of cytokines were measured by ELISA in patients with liver cirrhosis and in control group. Results The serum levels of IL-6 and IL-8 in patients with liver cirrhosis were significantly higher than in control group . Serum levels of IL-6 and IL-8 were significantly decreased in patients with restored hepatic function test after glutathione therapy. Condusion Liver dysfuntion maybe the reason of interleukin -6 and IL-8 elevation in patients with liver cirrhosis. Glutathione may have some curing role on liver cirrhosis. |
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| Keywords: | Liver cirrhosis IL-6 IL-8 Glutathione |
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