Levels of plasma TF and TFPI activities in patients with acute leukemia] |
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| Authors: | Y Zhu Z X Xie X F He J Z Han J C Li S L He |
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| Institution: | Department of Haemotology, Xiangya Hospital, Hunan Medical University, Changsha 410008. |
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| Abstract: | OBJECTIVE: To investigate the changes of plasma tissue factor(TF) and tissue factor pathway inhibitor(TFPI) activities in the patients with acute leukemia. METHODS: TF and TFPI activities were measured by using chromogenic assays. RESULTS: Plasma TF activity in the patients with acute leukemia was higher and TFPI activity was lower than those in normal(P < 0.01). In 7 patients who underwent the first chemotherapy, the plasma TF activity was decreased after chemotherapy(P < 0.01), while TFPI activity increased(P < 0.05). CONCLUSION: The unbalance between plasma TF and TFPI activities contributes to the coagulant disorders in acute leukemia. |
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