结肠癌患者手术前后CD69和IL-2变化的临床研究

目的了解结肠癌患者围手术期的免疫功能变化,探讨结肠癌组织切除对免疫功能的影响。方法应用流式细胞仪检测33例结肠癌患者手术前后外周血中T淋巴细胞CD69的表达百分率及IL-2的表达水平,并与对照组进行比较分析。结果结肠癌组患者术后第1天CD69表达百分率高于术前(P<0.01),术后第1、3、5、10天CD69表达百分率无明显变化;结肠癌组IL-2的表达水平术后1、3d与对照组相比无变化,第5天IL-2表达水平高于对照组(P<0.05),第10天IL-2表达水平同术前相比明显升高(P<0.01)。结论结肠癌患者术前免疫功能低下,术后活化T细胞明显增多,表明切除肿瘤有利于提高患者的免疫功能,增强机体的抗癌能力,提高机体的自体免疫机能。

Study on the Activity of CD69 and IL-2 before and after Operation in Colon Cancer Patients

Objective To test the change of immunity function after colon cancer operation. Methods Test the activity of CD69 and level of IL-2 by cell flow cytometer after colon cancer operation in 33 cases. Results The activity of CD69 was significantly higher after operation 1st day compared with nonoperation patients, and the activity of CD69 expression is unchange from the after operation 3 d to 10 d. The level of IL-2 was nondifferent from the first day to third day after operation. The level of IL-2 was higher 5 d after operation than the control group(P<0.05 ), the level of IL-2 10 d after operation was significantly higher than unoperation group(P<0.01). Conclusion The immunity function is inhibited in colon cancer patients. The ability of anticancer and immunity function is improved after colon cancer operation.