| 基因重组/尿卵泡刺激素在体外受精-胚胎移植周期临床效果的比较 |
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| 引用本文： | 杨宗芝,李波,薛伟,宋东坡. 基因重组/尿卵泡刺激素在体外受精-胚胎移植周期临床效果的比较[J]. 生殖医学杂志, 2008, 17(5): 339-341 |
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| 作者姓名： | 杨宗芝 李波 薛伟 宋东坡 |
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| 作者单位： | 青岛市妇女儿童医疗保健中心,青岛,266011 |
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| 摘 要： | 目的评估基因重组和尿卵泡刺激素在体外受精-胚胎移植(IVF-ET)周期中临床效果的差异。方法对单纯输卵管性因素行IVF-ET 90例患者,随机分为两组。分别给予尿卵泡刺激素(u-FSH)与基因重组卵泡刺激素(r-FSH)促排卵的结果进行比较。结果u-FSH组卵子成熟率显著高于r-FSH组(P<0.01),而平均费用、人绒毛膜促性腺激素(hCG)日血清雌二醇(E2)水平低于r-FSH组(P<0.05)。两组受精率、优质胚胎率、种植率、妊娠率、平均获卵率、促排卵天数、促性腺激素(Gn)用量、局部反应、内膜厚度差异无显著性(P>0.05)。结论在IVF-ET治疗周期中,u-FSH在不影响妊娠率的同时较r-FSH更有助于卵泡成熟,具有较大的价格优势,并有降低卵巢过度刺激综合征(OHSS)发生的趋势。因此,u-FSH有可能成为IVF-ET治疗周期中较为理想的促排卵药物。
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| 关 键 词： | 体外受精-胚胎移植 不育症 卵泡刺激素 基因重组 |
Comparison of the clinical effect of recombinant FSH and urinary FSH preparation on IVF-ET outcome |
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| YANG Zong-zhi,LI Bo,XUE Wei,SONG Dong-po. Comparison of the clinical effect of recombinant FSH and urinary FSH preparation on IVF-ET outcome[J]. Journal of Reproductive Medicine, 2008, 17(5): 339-341 |
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| Authors: | YANG Zong-zhi LI Bo XUE Wei SONG Dong-po |
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| Affiliation: | YANG Zong-zhi,LI Bo,XUE Wei,SONG Dong-poReproductive Medicine Center,Qingdao Women & Children Hospital,Qingdao 266012 |
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| Abstract: | Objective:To compare the in-vitro fertilization and embryo transfer(IVF-ET) outcome in different protocols using urinary or recombinant FSH preparation.Methods:Ninety infertility patients with the only cause of salpingemphraxis undergoing IVF-ET cycles were randomly divided into 2 groups,and received either urinary FSH(u-FSH) or recombinant(r-FSH),in combination with long GnRH-a protocol to induce ovulation.Results:The maturing rate of oocytes in u-FSH group was significantly higher than that in r-FSH group... |
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| Keywords: | In vitro fertilization-embryo transfer Infertility Follicle stimulating hormone Gene recombination |
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