Basic neural transplantation techniques. I. Dissociated cell suspension grafts of embryonic ventral mesencephalon in the adult rat brain |
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| Affiliation: | 1. Department of Physiology, College of Medicine, University of Kentucky, Lexington, KY 40536, United States;2. Epilepsy Center, University of Kentucky, Lexington, KY 40536, United States;3. Center for Advanced Translational Stroke Science, University of Kentucky, Lexington, KY 40536, United States;4. Spinal Cord and Brain Injury Research Center (SCoBIRC), University of Kentucky, Lexington, KY 40536, United States;1. Department of Drug Discovery and Biomedical Sciences, Medical University of South Carolina, Charleston SC, United States;2. Department of Neuroscience, Medical University of South Carolina, Charleston SC, United States;3. Center of Biomedical Imaging, Medical University of South Carolina, Charleston SC, United States;4. Health Sciences and Research, College of Health Professions, Medical University of South Carolina, Charleston, SC, United States;5. Ralph H. Johnson VA Medical Center, Charleston, SC, United States;6. Department of Pharmacy & Toxicology, College of Pharmacy, University of Arizona, Tucson, AZ, United States;1. Area of Cellular Biology, Department of Experimental Biology, University of Jaén, Campus Las Lagunillas s/n, 23071, Jaén, Spain;2. Area of Biochemistry and Molecular Biology, Department of Experimental Biology, University of Jaén, Campus Las Lagunillas s/n, 23071, Jaén, Spain;3. Area of Bioinformatics, Instituto Maimónides de Investigación Biomédica de Córdoba, Edificio consultas externas Hospital Universitario Reina Sofía, 14004 Córdoba, Spain |
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| Abstract: | Lesions and grafts in the nigrostriatal dopamine system in rats is widely used as a model of degeneration and regeneration in the CNS, and the development for alternative strategies for treatment in Parkinson's disease. The methods of preparing a dissociated cell suspension of embryonic rat substantia nigra and its transplantation into the brain of adult rats are described. This is the first of a series of methodological reports on the basic methodology and refinements of neural transplantation techniques in the mammalian central nervous system. |
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