Arzneimittelexantheme bei Therapie der HIV-Infektion mit Efavirenz und Nevirapin |
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Authors: | M Hartmann J Brust D Schuster F Mosthaf M Procaccianti J A Rump H Klinker D Petzoldt |
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Institution: | 1. Hautklinik, Universit?t, Heidelberg 6. Hautklinik, Universit?t, Vo?stra?e 2, 69115, Heidelberg 2. Schwerpunktpraxis, Mannheim 3. Schwerpunktpraxis, Karlsruhe 4. Schwerpunktpraxis, Freiburg 5. Medizinische Universit?tsklinik, Würzburg
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Abstract: | Efavirenz and nevirapine are frequently used drugs in antiretroviral therapy. Rashes are common side effects of these drugs. In this study, we examined the characteristics of efavirenz- and nevirapine-associated rashes.This prospective nonrandomized multicenter study included 662 HIV-infected patients (efavirenz: 325, nevirapine: 337) to determine incidence, duration, cross-reactivity, and outcome upon reexposure.Of the treated patients, 4.5% (n=30) developed rashes (nevirapine: 2.4% and efavirenz: 6.4%). In four patients treatment was not interrupted. Three patients were re-exposed to the initial drug without any side effects.Therapy with nevirapine or efavirenz does not have to be interrupted if rashes exhibit no blistering, mucosal manifestations, or systemic signs. |
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