出血怀休克病人动脉血浆一氧化氮和乳酸浓度的变化与预后的关系

目的 探讨动脉血浆一氧化氮（ＮＯ）和乳酸浓度变化与出血性休克病人预后的关系。方法 应用荧光分光光度法和光电比色法测定了４８例创伤出血性休克病人动脉血中ＮＯ和乳酸２的动态变化,并与３０例择期手术病人进行对比,同时观察ＮＯ和乳酸和创伤指数及预后的关系。结果 出血性休克组ＮＯ浓度明显低于择期手术组,乳酸浓度明显高于择期手术组,ＮＯ浓度与创伤指数和乳酸浓度呈明显负相关。１３例术后并发败血症的病人ＮＯ浓度仍

Arterial plasma nitric oxide and lactate level in hemorrhagic shock patients

OBJECTIVE: To investigate the relationship between arterial plasma nitric oxide(NO), lactate (LA) concentration and prognosis of hemorrhagic shock patients. METHODS: The blood levels of a NO and LA were measured with fluoropholometry and colorimetry in 48 hemorrhagic shock patients, and other 30 patients for selective surgery served as controls. RESULTS: NO level was significantly lower and LA level was significantly higher in the hemorrhagic shock group than that of the control group respectively. NO level had a negative correlation with LA level and trauma index. NO level in the patients complicated by sepsis was still lower than that of the control group. CONCLUSION: Decrease of NO level may be a main cause of disturbance of microcirculation and increase of LA. The lower the NO level, the higher the LA level, the worse the prognosis. So NO and LA level play an important role in forecasting progress of hemorrhagic shock patients.