硫氮Zhuo酮对慢性肺心病急性发作期的血流动力学及氧动力学效应

目的 了解硫氮Ｚｈｕｏ酮对慢性阻塞性肺病（ＣＯＰＤ）所致肺动脉高压的治疗效果。方法 对１１例慢性肺心病急性发作期患者给予静脉注射硫氮Ｚｈｕｏ酮治疗并作动态血流动力学及氧动力学监测。结果 发现静脉注射硫氮Ｚｈｕｏ酮可迅速降低肺动脉压、肺血管阻力指数和右心房平均压（分别降低０．６２￣１．２７ｋＰａ、１４．０ｋＰａ·ｓ＾－１·Ｌ＾－１和０．２７￣０．４０ｋＰａ,Ｐ均〈０．０５）;心率明显下降（下降２５￣

The effects of diltiazem on pulmonary hemodynamics and oxygenation in copd induced pulmonary hypertension

OBJECTIVE: To study hemodynamic the effects of intravenous diltiazem on COPD induced pulmonary hypertention. METHODS: 11 cases in exacerbation stage were chosen to study. Swan-Ganz catheterization were taken for hemodynamic monitoring. RESULTS: After the administration of diltiazem, pulmonary vascular resistance, pulmonary pressure, right artrial pressure and heart rate decreased significantly (the extents decreased were 14.0 kPa.s-1.L-1, 0.62-1.27 kPa, 0.27-0.40 kPa and 25-30 beats/min respectively, P < 0.05); Cardiac output and stroke volume increased identically (the extents increased were 0.3-0.6 L.min-1.m-2 and 5-9 ml.beat-1.m-2 respectively, P < 0.05); No significant changes found in Qs/Qt, PaO2 and systemic blood pressure. CONCLUSION: Our study showed that diltiazem produces beneficial pulmonary hemodynamic effects without oxygenation compromise in COPD cases and has a strong indication in those who complicated with superventricular tachycardia.