| 耳缘静脉放血对偏头痛家兔模型PAG区G蛋白的影响 |
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| 引用本文： | 杨佃会,阚俊祯,马祖彬,韩,晶.耳缘静脉放血对偏头痛家兔模型PAG区G蛋白的影响[J].山东中医药大学学报,2014(1):56-57,61. |
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| 作者姓名： | 杨佃会 阚俊祯 马祖彬 韩 晶 |
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| 作者单位： | [1]山东中医药大学附属医院,山东济南250011 [2]单秋华全国名老中医药专家传承工作室,山东济南250011 [3]山东中医药大学第二附属医院,山东济南250001 |
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| 基金项目： | 山东省自然科学基金（编号：ZR2009CM058） |
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| 摘 要： | 目的:观察耳缘静脉放血对偏头痛家兔模型中脑导水管周围灰质(PAG)G蛋白含量的影响,初步揭示耳缘静脉放血的中枢镇痛调控机制。方法:30只新西兰家兔按随机数字表法分为三组,分别为耳缘静脉放血组、模型组和空白组。采用硝酸甘油复制偏头痛家兔模型,分别在第1天、第4天、第7天造模30 min后耳缘静脉放血。免疫组化法观察家兔模型PAG区G蛋白含量的变化。结果:耳缘静脉放血组家兔模型PAG区G蛋白含量明显降低,与模型组比较有非常显著性差异(P0.01)。结论:耳缘静脉放血可明显降低偏头痛家兔模型PAG区G蛋白含量,参与镇痛效应。
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| 关 键 词： | 耳缘静脉放血 偏头痛 G蛋白 家兔 实验研究 |
Effect of Ear-edge Vein Bloodletting on G Protein in PAG of Migraine Rabbit Models |
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| YANG Dianhui,KAN Junzhen,MA Zubinl,HAN Jing.Effect of Ear-edge Vein Bloodletting on G Protein in PAG of Migraine Rabbit Models[J].Journal of Shandong University of Traditional Chinese Medicine,2014(1):56-57,61. |
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| Authors: | YANG Dianhui KAN Junzhen MA Zubinl HAN Jing |
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| Institution: | 1.Affiliated Hospital of Shandong University of Traditional Chinese Medicine,Jinan 250011 ,China;2.Famous Traditional Chinese Medical Doctor Shan Qiuhua＇s Inheritance Studio,Jinan 250011,China;3.the Second Af-filiated Hospital of Shandong University of Traditional Chinese Medicine,Jinan 250001 ,China) |
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| Abstract: | Objective：To observe the effect on G protein in periaqueductal gray（PAG） of the rabbit models of migraine by the therapy of ear-edge vein bloodletting,revealing the central mechanism of analgesic regu-lation. Methods：Total 30 New Zealand rabbits were randomly divided into 3 groups,ear-edge vein bloodlet-ting group,model group and blank group. By subcutaneous injecting nitroglycerin in the rabbits＇ neck,the migraine models were successfully copied. The ear-edge vein blood were letted after 30 minutes of molding, once every 3 days,3 times a course. Then,we observed the expression of G protein in PAG of rabbits by immunohistochemical method. Results ：The expression of G protein in PAG of the ear-edge vein bloodletting group was significantly reduced compared with the model group（P〈0.01 ）. Conclusion：The therapy of ear-edge vein bloodletting has analgesic effect,which can decrease the expression of G protein in PAG of rabbit models of migraine. |
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| Keywords: | ear-edge vein bloodletting migraine G protein rabbit experimental study |
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