P53、MVD在非小细胞肺癌中的表达及其相关性

目的:研究P53、MVD在非小细胞肺癌中的表达及其相关性,探讨其在非小细胞肺癌发生、发展中的作用。方法:采用免疫组织化学SP法检测80例非小细胞肺癌组织、20例肺良性病变组织中P53蛋白的表达,并对肺癌组织中CD34单抗标记的血管计数MVD。结果:肺癌组织P53阳性表达率明显高于肺良性病变组织(P<0.05)。P53表达与肺癌患者的组织学类型无关(P>0.05),与肺癌组织的分化程度、TNM分期及淋巴结转移均有关(P<0.05)。在肺癌组织中,P53蛋白表达阳性组MVD明显高于P53蛋白表达阴性组(P<0.05)。结论:P53可能与肺癌的发生、发展有关。肺癌组织中MVD与P53表达密切相关,突变型p53基因在肺癌血管形成中具有重要作用。

P53 and MVD expressions and their correlations in non-small cell lung cancer

Objective:To study the expressions of P53 and microvessel density(MVD) and their correlations in non-small cell lung cancer(NSCLC),and discuss their significance in carcinogenesis and progression of lung cancer.Methods: The expressions of P53 and MVD in 80 non-small cell lung cancer tissues,20 benign lung tissues were examined by use of SP immunohistochemistry.The number of microvessel labelled by anti-CD34 monoclonal antibody in lung cancer tissues was calculated.Results: The positive rate of P53 expression in lung cancer tissues was significantly higher than that in benign tissues(P<0.05).No significant correlation was found between the P53 expression and histological type(P>0.05).P53 expression was closely related with cell differentiation grade,TNM stages and lymph node status of lung cancer.MVD in lung cancer tissues with positive expression of P53 was significantly higher than that with negative expression of P53(P<0.05).Conclusion: P53 may be closely related with carcinogenesis and development of lung cancer.MVD of lung carcinoma is closely related with the P53 expression.The mutant P53 gene could play an important role in the control of vascularization.