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Adjuvant Arthritis in young copper-deficient rats |
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| Authors: | R. Milanino E. Passarella G. P. Velo |
| Affiliation: | (1) Pharmacology Department, Research Division, Laboratori Glaxo S.p.A., Duncan Farmaceutici S.p.A, Via A. Fleming, 2, 37100 Verona, Italy;(2) Istituto di Farmacologia, University of Padova, Policlinico Borgo Roma, 37100 Verona, Italy |
| Abstract: | Adjuvant arthritis has been studied in young copper-deficient rats and a very strong inhibition of the disease following 60 days of deficient diet (0.4 ppm of copper) was found. No difference in lung prostaglandin synthesis and in rat stomach strip and colon reactivity to exogenous prostaglandins was noticed between controls and copper-deficient animals.These results are briefly discussed. |
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