组织多肽特异性抗原对胰腺癌患者的诊断价值 |
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引用本文: | 陆云,刘兴党,李鼎,邓守真. 组织多肽特异性抗原对胰腺癌患者的诊断价值[J]. 中华核医学杂志, 2009, 29(3): 194-196. DOI: 10.3760/cma.j.issn.0253-9780.2009.03.015 |
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作者姓名: | 陆云 刘兴党 李鼎 邓守真 |
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作者单位: | 复旦大学附属华山医院核医学科,上海,200040 |
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摘 要: | 目的对比分析组织多肽特异性抗原(TPS)与多个糖类抗原(CA)血清浓度,探讨TPS对胰腺癌的诊断价值。方法血清标本来自慢性胰腺炎患者33例,非胰腺恶性肿瘤患者35例,胰腺癌患者34例。TPS测量采用酶联免疫吸附测定(ELISA);CA19-9和CA125测定采用化学发光免疫分析;CA50和CA242测定采用免疫放射分析法。测量数据采用SPSS9.0统计软件进行统计分析。结果胰腺癌患者血清TPS[(386.5±315.1)U/L]和CA19-9[(10820.9±389.7)kU/L]均明显高于慢性胰腺炎患者[分别为(86.2±28.1)U/L,(61.5±24.7)kU/L;F=936.42和2217.09,P均〈0.001]。其中,TPS灵敏度为70.6%(48/68),特异性57.4%(39/68);CA19-9灵敏度为82.4%(28/34),特异性77.9%(53/68)。联合使用TPS与CA19-9、CA50、CA125和CA242,可显著增加灵敏度(94.1%,32/34),减少漏诊率。结论TPS作为CA19-9的有益补充,可提高诊断胰腺癌的灵敏度。
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关 键 词: | 抗原,肿瘤 抗原,肿瘤相关,碳水化合物 胰腺肿瘤 |
Diagnostic value of tissue polypeptide specific antigen in serum for patients with pancreatic carcinoma |
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Affiliation: | LU Yun, LIU Xing-dang, LI Ding, et al. (Department of Nuclear Medicine, Hnashan Hospital of Fudan University, Shanghai 200040, China) |
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Abstract: | Objective To compare the diagnostic value of tissue polypeptide specific antigen (TPS) in serum, with the carbohydrate antigens (CA) 19-9, CA50, CA125 and CA242 in pancreatic carci-noma. Methods Serum TPS was measured with enzyme linked immunosorbent assay (ELISA). CA19-9 and CA125 were measured with chemiluminescent immunoassay. CAS0 and CA242 were measured with im-munoradiometric assay in 33 patients with pancreatitis, 34 patients with pathologically proven pancreatic car-cinoma, and 35 patients with non-pancreatic malignancies. Statistic analysis was carried out with SPSS 9.0 software. Results Patients with pancreatic carcinoma had relatively higher levels of TPS [(386.5± 315. 1) U/L] and CA19-9 [(10 820.9 ± 389.7) kU/L] when compared with patients with pancreatitis [(86. 2 ± 28.1) U/L and (61.5 ± 24.7) kU/L, respectively; F = 936. 42, P < 0. 001 ; F = 2217. 09, P < 0. 001], with a sensitivity and a specificity of 70.6% (48/68) and 57.4% (39/68), respectively, for TPS, and 82.4% (28/34) and 77.9% (53/68), respectively, for CA19-9. Diagnostic performance was further improved when TPS was assayed in combination with CA19-9, CA50, CA12.5 and CA242. Conclusion Serum TPS has an incremental value in complementing CA19-9 in the diagnosis of pancreatic carcinoma. |
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Keywords: | Antigens,neoplasms Antigens,tumor-associated,carbohydrate Pancreatic neoplasms |
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