组织多肽特异性抗原对胰腺癌患者的诊断价值

目的对比分析组织多肽特异性抗原（TPS）与多个糖类抗原（CA）血清浓度，探讨TPS对胰腺癌的诊断价值。方法血清标本来自慢性胰腺炎患者33例，非胰腺恶性肿瘤患者35例，胰腺癌患者34例。TPS测量采用酶联免疫吸附测定（ELISA）；CA19-9和CA125测定采用化学发光免疫分析；CA50和CA242测定采用免疫放射分析法。测量数据采用SPSS9．0统计软件进行统计分析。结果胰腺癌患者血清TPS（386．5±315．1）U／L]和CA19-9（10820．9±389．7）kU／L]均明显高于慢性胰腺炎患者分别为（86．2±28．1）U／L，（61．5±24．7）kU／L；F=936．42和2217．09，P均〈0．001]。其中，TPS灵敏度为70．6％（48／68），特异性57．4％（39／68）；CA19-9灵敏度为82．4％（28／34），特异性77．9％（53／68）。联合使用TPS与CA19-9、CA50、CA125和CA242，可显著增加灵敏度（94．1％，32／34），减少漏诊率。结论TPS作为CA19-9的有益补充，可提高诊断胰腺癌的灵敏度。

Diagnostic value of tissue polypeptide specific antigen in serum for patients with pancreatic carcinoma

Objective To compare the diagnostic value of tissue polypeptide specific antigen (TPS) in serum, with the carbohydrate antigens (CA) 19-9, CA50, CA125 and CA242 in pancreatic carci-noma. Methods Serum TPS was measured with enzyme linked immunosorbent assay (ELISA). CA19-9 and CA125 were measured with chemiluminescent immunoassay. CAS0 and CA242 were measured with im-munoradiometric assay in 33 patients with pancreatitis, 34 patients with pathologically proven pancreatic car-cinoma, and 35 patients with non-pancreatic malignancies. Statistic analysis was carried out with SPSS 9.0 software. Results Patients with pancreatic carcinoma had relatively higher levels of TPS (386.5± 315. 1) U/L] and CA19-9 (10 820.9 ± 389.7) kU/L] when compared with patients with pancreatitis (86. 2 ± 28.1) U/L and (61.5 ± 24.7) kU/L, respectively; F = 936. 42, P < 0. 001 ; F = 2217. 09, P < 0. 001], with a sensitivity and a specificity of 70.6% (48/68) and 57.4% (39/68), respectively, for TPS, and 82.4% (28/34) and 77.9% (53/68), respectively, for CA19-9. Diagnostic performance was further improved when TPS was assayed in combination with CA19-9, CA50, CA12.5 and CA242. Conclusion Serum TPS has an incremental value in complementing CA19-9 in the diagnosis of pancreatic carcinoma.