Polycythemia Vera treated with 32P and Myleran: Development of chronic granulocytic leukemia with chromosomal abnormalities in one patient |
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| Authors: | Per Stavem Carl B van der Hagen Else Vogt Kjell Sandnes |
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| Institution: | Section of Hematology, Rikshospitalet;Department of Pathology, Rikshospitalet;Institute of Medical Genetics, University of Oslo, Norway;Blood Group Reference Laboratory, Statens Institute for Folkehelse, Oslo, Norway |
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| Abstract: | Chronic granulocytic leukemia developed in a 59–year-old woman who had previously received a total of 21 mCi 32P for polycythemia Vera. She was treated with Myleran (busulphan) for her chronic granulocytic leukemia. Cytogenetic studies revealed deletion of chromosomes No. 8 and 12, and translocation between 1 and 8. The patient also developed a severe autoimmune hemolytic anemia, for which she received prednisone treatment. She died with a perforated stomach ulcer. |
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