| 康强硒、硒多糖对染砷大鼠肝细胞增殖周期的影响 |
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| 引用本文： | 郑金平,祝寿芬,窦岩.康强硒、硒多糖对染砷大鼠肝细胞增殖周期的影响[J].中国公共卫生,2000,16(11):999-1001. |
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| 作者姓名： | 郑金平 祝寿芬 窦岩 |
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| 作者单位： | 山西医科大学太原030001 |
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| 基金项目： | 山西省自然科学基金资助项目 |
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| 摘 要： | 选用Ｗｉｓｔａｒ大鼠随机分为对照组（蒸馏水）、砷组（４．６ｍｇ／ｋｇＡｓ２Ｏ３）、砷＋康强硒①组（４．６ｍｇ／ｋｇ＋０．１ｍｇＳｅ＾３＋／ｋｇ）、砷＋康强硒②组（４．６ｍｇ／ｋｇ＋０．２ｍｇＳｅ＾３＋／ｋｇ）、砷＋硒多糖组（４．６ｍｇ／ｋｇ＋４０ｍｇ／ｋｇ）５组。流式细胞仪测定肝细胞周期，病理组织切片观察病理改变，结果染砷组大鼠肝细胞比对照组Ｇ０／Ｇ１期细胞数显著减少，Ｓ和Ｇ２＋Ｍ期细胞数显著增多
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| 关 键 词： | 康强硒 硒多糖 肝细胞增殖周期 砷中毒 |
The Effect of Kangqiang Selenium and Selenium Polysaccharide on Cell Cycle of Livers of Rats Poisoned with Arsenic |
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| Zheng JinPing,et al..The Effect of Kangqiang Selenium and Selenium Polysaccharide on Cell Cycle of Livers of Rats Poisoned with Arsenic[J].Chinese Journal of Public Health,2000,16(11):999-1001. |
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| Authors: | Zheng JinPing |
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| Institution: | Tai Yuan 030001 |
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| Abstract: | To study the effect of arsenic on cell cycle of livers of rats and
the antagonism of Kangqiang Selenium and Selenium Polysaccha-
ride against arsenic. The cell cycle was observed with the flow cy-
tometer. The percentage of cell in G0/G1 phase was decreased, but
the percentage of cell in S and G2 + M phases and the proliferation
index( IP)、 the DNA relate content (DNARc) were increase great-
ly, which shows that the production of DNA increased and the cell
were arrested in G2 + M phases. The selenium compounds
(Kangqiang Selenium and Selenium Polysaccharide )could protect
against the effects of arsenic on livers cell cycle in rats. The antag-
onism of Kangqiang Selenium with 0. 2rmgSe3+ /kg was stronger
than it with 0. lmgSe3+/kg and same as Selenium Polysaccha-
ride. It shows that arsenic could interfere with the liver cell cycle.which was related to the liver cancer induced by arsenic. Kangqing
Selenium and Selenium Polysaccharide could actively protect a-
gainst the effects of arsenic. |
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| Keywords: | Arsenic Selenium compound Liver Cell cycleAntagonism |
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