高压氧疗法在肝硬化形成过程中预防和治疗作用的实验研究

目的　在肝硬化进程中低氧血症可能起着重要作用 ,为探索其新疗法 ,我们实施了高压氧对肝纤维化进程影响的实验研究。方法　用 60 %四氯化碳将 75只Wistar大鼠致肝硬化 ,其间大鼠被随机分为 :肝硬化对照组 ,常压氧组 ,压力对照组 ,2 0ATA(atmosphereabsolute,ATA)组和 2 5ATA组 ;治疗结束后观察肝功能检查及肝脏病理组织变化。结果　 2 5ATA下给氧可使肝功能明显改善 (P <0 0 5 ) ;余者仅对部分肝功能指标有影响。光镜 :肝脏病理组织学改变有所好转。讨论　高压氧治疗通过改善机体有氧代谢 ,在药物毒性肝硬化制备过程中可延缓肝硬化进程。

Effects of hyperbaric oxygenation during formation of liver cirrhosis

Objective To investigate the preventive and therapeutic effects of hyperbaric oxygenation on liver cirrhosis. Methods A total of 75 Wistar rats were randomized into 5 groups: normal pressure oxygenation group (group A), 2.0 ATA oxygenation group (group B), 2.5 ATA oxygenation group (group C), 2.5 ATA baric control group (group D) and liver cirrhotic control group (group E). After the periodic therapy during the preparation of liver cirrhosis, liver function and pathohistological examination was performed. Results The liver function was perfected by 2.5 ATA oxygenation and was partially improved in other 4 groups (P<0.05). There were some pathohistological changes between group E and groups A, B and C. Conclusions During the formation of toxin induced liver cirrhosis, hyperbaric oxygenation can delay the deveopment of the cirrhosis by improving the aerobic metabolism.