| 联合检测血清VEGF、CA125和CEA对41例中晚期肺癌患者三维适形放疗疗效评估价值 |
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| 引用本文： | 马虎,柏玉举,李宁,杨卫兵,张廷友. 联合检测血清VEGF、CA125和CEA对41例中晚期肺癌患者三维适形放疗疗效评估价值[J]. 重庆医学, 2010, 39(4) |
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| 作者姓名： | 马虎 柏玉举 李宁 杨卫兵 张廷友 |
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| 作者单位： | 遵义医学院附属医院胸部肿瘤科,贵州,563000;遵义医学院附属医院胸部肿瘤科,贵州,563000;遵义医学院附属医院胸部肿瘤科,贵州,563000;遵义医学院附属医院胸部肿瘤科,贵州,563000;遵义医学院附属医院胸部肿瘤科,贵州,563000 |
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| 摘 要： | 目的探讨联合检测中晚期肺癌患者血清血管内皮生长因子(VEGF)、癌抗原125(CA125)和癌胚抗原(CEA)在三维适形放疗疗效评估中的价值。方法采用酶联免疫吸附实验(ELISA)和(或)免疫放射分析法(IRMA)测定41例中晚期肺癌患者放疗前、后及放疗后2个月血清VEGF、CA125和CEA水平,以25例健康者测定值为对照。结果肺癌组血清VEGF、CA125和CEA明显高于对照组,肺癌组VEGF、CA125和CEA在放疗后均低于放疗前(P<0.05)。结论联合检测血清VEGF、CA125和CEA对中晚期肺癌患者病情变化及估计预后有一定的参考价值,血清中VEGF、CA125和CEA水平与肺癌病情变化呈负相关。
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| 关 键 词： | 肺癌 三维适形放疗 血管内皮生长因子 癌抗原125 癌胚抗原 |
Significance of combined determination of vascular endothelial growth factor,CA125 and carcinoembryanic antigen in peripheral blood of patients with non-small cell lung cancer |
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| MA Hu,BAI Yu-ju,LI Ning,et al.. Significance of combined determination of vascular endothelial growth factor,CA125 and carcinoembryanic antigen in peripheral blood of patients with non-small cell lung cancer[J]. Chongqing Medical Journal, 2010, 39(4) |
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| Authors: | MA Hu BAI Yu-ju LI Ning et al. |
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| Affiliation: | Department of Cancer;Affiliated Hospital;Zunyi Medical College;Zunyi 563000;China |
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| Abstract: | Objective To evaluate whether the detection of serum vascular endothelial growth factor (VEGF) combined with cancer antigen 125 (CA125) and carcinoembryonic antigen (CEA) in advanced lung cancer patients treated by 3-dimensional conformal radiation therapy would reflect the prognosis of NSCLC.Methods Serum VEGF,CEA and CA125 were determined by enzyme-linked immunosorbent assay(ELISA) and (or) Immunoradiometric assay ( IRMA)in 41 patients with adcanced NSCLC treated by 3-dimensional conformal Radiation thera... |
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| Keywords: | pulmonary neoplasm 3-dimensional conformal Radiation therapy vascular Endothelial Growth Factor cancer antigen 125 carcinoembryonic antig |
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