Effect of omeprazole on the course of associated esophagitis and laryngitis |
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Authors: | Daniel Jaspersen R Weber C -H Hammar W Draf |
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Institution: | (1) Department of Gastroenterology Communication Disorders, Academic Hospital Fulda, Pacellialle 4-6, D-36043 Fulda, Germany;(2) Department of ENT, Head, Neck and Facial Plastic Surgery, Communication Disorders, Academic Hospital Fulda, Pacellialle 4-6, D-36043 Fulda, Germany |
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Abstract: | Esophagitis has increasingly been implicated as a cause of chronic laryngitis and there is some evidence that gastro-esophageal
reflux disease (GERD) is more common in patients with laryngitis. The aim of this study was to evaluate whether patients with
esophagitis and laryngitis responded to treatment with omeprazole. Of 74 consecutive patients with endoscopically proven GERD,
21 had laryngitis. These 21 patients with associated esophagitis and chronic laryngitis were treated for 4 weeks with omeprazole
40 mg per day. After 2 weeks of treatment and at the conclusion of the study, 2 weeks later, esophagoscopy and laryngoscopy
were performed and the patients responded to a questionnaire on their symptoms. The follow-up period was 1 year. Twenty-one
of the 74 patients (28.4%) had esophagitis (grade I,n=12; grade II,n=9) and associated laryngitis (grade I,n=14; grade II,n=7). The severity of the esophagitis accorded with the severity of the laryngitis. After 2 weeks' treatment with omeprazole,
both the esophageal and the laryngeal symptoms had improved in all 21 patients. Endoscopically, the healing rates were 62%
for esophagitis and 33.3% for laryngitis. At the end of the study period, at 4 weeks, all patients were symptom-free and the
esophagitis and laryngitis had healed completely. No patient suffered from drug-induced side effects. Patients with associated
laryngitis and esophagitis should be given adequate anti-reflux therapy. Both the laryngeal and esophageal symptoms improved
with the omeprazole treatment, suggesting that reflux was the underlying etiology. |
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Keywords: | omeprazole esophagitis laryngitis |
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