Short-term effects of treatment with simvastatin on testicular function in patients with heterozygous familial hypercholesterolaemia |
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| Authors: | K. Purvis A. Tollefsrud H. Rui E. Haug J. Norseth L. Viksmoen L. Ose H. Lund |
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| Affiliation: | (1) Andrology Laboratory, The National Hospital, Oslo, Norway;(2) Hormone Laboratory, Aker Hospital, Oslo, Norway;(3) Fürst Medical Laboratory, Oslo, Norway;(4) Medical Department, MSD Norway, Drammen, Norway;(5) Lipid Clinic, The National Hospital, Oslo, Norway |
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| Abstract: | Summary The effects of simvastatin 40 mg per day for 14 weeks on the pituitary-testis axis of 19 men with familial hypercholesterolaemia have been examined in a single-blind study.Simvastatin significantly reduced serum low density lipoprotein (LDL) cholesterol and triglycerides by 45% and 30%, respectively, and significantly increased high density lipoprotein (HDL) cholesterol by 15%.The alterations, which were stable 4 weeks after the start of treatment, were not associated with any significant change in sperm quality, the seminal plasma concentrations of various sex gland products (prostate-specific acid phosphatase, polyamines, citrate, fructose,  -glucosidase), or the serum concentrations of cortisol, testosterone, LH, FSH, or prolactin.It is concluded that a short-term reduction in circulating LDL-cholesterol has no marked effect on testicular function or sperm quality. |
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| Keywords: | Hypercholesterolaemia Simvastatin heterozygous familial accessory sex glands semen sperm LDL testicular function adverse effect |
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