| Abstract: | An antigen common to continuous human epithelial cell lines (CHC) and gastric mucosa, described by the writers previously, was studied. The antigen was found in one other cell line (MDA-MV-231), derived from carcinoma of the human breast, not contaminated by Hela cells. The antigen described was found in exophytically growing adenocarcinomas of the stomach and in the mucosa of a stomach affected by cancer at a distance of 10–12 cm from the site of the lesion. The antigen was not found in endophytically growing carcinomas of the stomach or in areas close to a gastric ulcer. The antigen is not a glycoprotein, for glycoprotein fractions obtained with the aid of 1.2 M perchloric acid from homogenate of normal gastric mucosa and extract E16b were inactive in the immunodiffusion test with a sensitive serum. The antigen described has the electrophoretic mobility of  2- 1-globulin. The antigen is interesting because its presence or absence may perhaps help to establish the initial type of cell from which a gastric carcinoma developed and to identify more precisely the histological form of a gastric carcinoma.Laboratory of Sarcoma-Leukemia Viruses and Laboratory of Clinical Biochemistry, Oncologic Scientific Center, Academy of Medical Sciences of the USSR, Moscow. (Presented by Academician G. V. Vygodchikov.) Translated from Byulleten' Éksperimental'noi Biologii i Meditsiny, Vol. 86, No. 12, pp. 744–747, December, 1978. |
