一氧化氮合酶基因转移在心血管疾病治疗中的研究进展

基因治疗包括功能基因转移至宿主细胞 ,用于校正特定基因的功能缺陷或减轻疾病的症状。对于心血管疾病的基因转移 ,腺病毒载体最有效。该文从方法学上回顾了血管NOS基因转移领域的最新进展以及NOS基因转移对重要心血管疾病的潜在应用。NOS基因转移方法在动物模型中具有可行性 ,但是 ,当前可用的载体还有许多技术和安全限制。在用于人类心血管疾病NOS基因治疗前必须给予克服

Effectsof nitric oxide synthase gene transfer in cardiovascular diseases

Gene therapy involves the transfer of a functional gene into host cells to correct the malfunction of a specific gene or to alleviate the symptoms of a disease. For gene transfer to the cardiovascular system, adenoviral vectors are the most efficient means of transfer. We reviewed the methods of current progress in the field of vascular NOS gene transfer and the potential use of NOS gene therapy for important cardiovascular diseases. Although the feasibility of the NOS gene transfer approach has been demonstrated in animal models, currently available vectors have a number of technical and safety limitations that have to be solved before human NOS gene therapy for cardiovascular diseases can be attempted.