长效睾丸酮合并环孢霉素A治疗慢性再生障碍性贫血

目的：探讨进一步提高慢性再生障碍性贫血（ＣＡＡ）疗效的方法。方法：长效睾丸酮（ＴＬＤ）单用（１５例）及合用环孢霉素Ａ（ＣｓＡ）（３０例）治疗ＣＡＡ４５例。按全国统一标准评定疗效，并采用甲基纤维素培养法观察治疗前、后骨髓造血祖细胞水平的变化。结果：ＴＬＤ＋ＣｓＡ组有效率为８３．３％，高于单用ＴＬＤ组的６０．０％，且ＴＬＤ＋ＣｓＡ组有效者骨髓造血祖细胞（ＢＦＵ－Ｅ及ＣＦＵ－ＧＭ）恢复明显优于单用ＴＬＤ组有效者并更为迅速，两组间无效者骨髓ＢＦＵ－Ｅ及ＣＦＵ－ＧＭ水平无明显变化。结论：ＴＬＤ＋ＣｓＡ治疗ＣＡＡ疗效不仅高于单用ＴＬＤ，且其有效者血液学恢复更为完全。

Treatment of chronic aplastic anemia with triolandren and cyclosporin A

OBJECTIVE: To explore more effective regimen for chronic aplastic anemia (CAA). METHODS: Forty-five cases of CAA were treated with triolandren (TLD) (15 cases) or TLD and cyclosporin A (CsA) (30 cases). RESULTS: The response rate of TLD-CsA group (83.3%) was higher than that of TLD group (60.0%), furthermore, the recovery of bone marrow colony-forming cell (CFC) number of the responding patients was more complete and rapid in TLD-CsA group than in TLD group. Bone marrow CFC number had no significant change of all nonresponding patients in both groups. CONCLUSION: The response rate of TLD-CsA was higher than that of TLD alone, and the recovery of bone marrow CFC number of the responding patients was more complete and rapid in TLD-CsA group.