| 热化疗对颌面部鳞癌细胞热休克蛋白70表达的影响 |
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| 引用本文： | 王升志,王锂,高向东,成洲,毕洪广,王大章. 热化疗对颌面部鳞癌细胞热休克蛋白70表达的影响[J]. 华西口腔医学杂志, 2005, 23(4): 277-279 |
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| 作者姓名： | 王升志 王锂 高向东 成洲 毕洪广 王大章 |
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| 作者单位： | 1.青岛大学医学院附属烟台毓璜顶医院 口腔颌面外科,山东 烟台264000;2.山东烟台第一中学医务所 口腔科,山东 烟台264001;3.四川大学华西口腔医学院 口腔颌面外科教研室,四川 成都610041 |
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| 基金项目： | 山东省优秀中青年科学家科研奖励基金资助项目(03BS038)，广东省医学科研课题基金资助项目(A2002434) |
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| 摘 要： | 目的 探讨热化疗对颌面部鳞癌细胞热休克蛋白(HSP)70表达的影响。方法 12例鳞癌患者给予每周2次,5周10次为1个疗程的热化疗处理。12例患者均静脉注射平阳霉素8 mg,43℃微波热疗40 min。于患者治疗前及治疗5次后取肿瘤组织制作标本。用SP免疫组织化学法观察肿瘤细胞HSP70的表达。结果 热化疗1疗程结束后12例患者肉眼未见明显包块,免疫组织化学染色提示治疗中癌细胞HSP70表达增多。结论 热化疗可以明显提高HSP70在肿瘤细胞中的表达,HSP70通过其抗原递呈等系列免疫效应,发挥抗肿瘤作用。
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| 关 键 词： | 热化疗 热休克蛋白 肿瘤 |
| 文章编号： | 1000-1182(2005)04-0277-03 |
| 收稿时间： | 2005-03-03 |
| 修稿时间： | 2005-03-03 |
Influence of the Expression of Heat Shock Protein 70 in Maxillofacial Squamous Cell Carcinoma by Themochemotherapy |
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| WANG Sheng-zhi,WANG Li,GAO Xiang-dong,CHENG Zhou,BI Hong-guang,WANG Da-zhang. Influence of the Expression of Heat Shock Protein 70 in Maxillofacial Squamous Cell Carcinoma by Themochemotherapy[J]. West China journal of stomatology, 2005, 23(4): 277-279 |
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| Authors: | WANG Sheng-zhi WANG Li GAO Xiang-dong CHENG Zhou BI Hong-guang WANG Da-zhang |
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| Affiliation: | 1. Dept. ofOralandMaxillofacial Surgery,The Affiliated Yantai YuHuang DingHospital ofMedical College,Qingdao University, Yantai264000,China;2.Dept. ofStomatology,The Infirmary ofthe No.1Middle School of Yantai, Yantai264001, China;3.Dept. ofOralandMaxillofacial Surgery, West China College ofStomatology, Sichuan University, Chengdu610041, China |
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| Abstract: | OBJECTIVE: To study the influence of thermochemotheraphy on the expression of HSP70 in maxillofacial squamous cell carcinoma. METHODS: 12 patients were treated with thermochemotheraphy twice a week, altogether 10 times. After 8 mg of Pingyangmycin infused, the patients were treated with microwave hyperthermia at 43 degrees C for 40 min. The part of carcinoma tissue was removed with surgical operations at before treatment and aftre five times of treatment. The expression of HSP70 in tumor cells was determined by SP immunohistochemcial method. RESULTS: The expression of HSP70 in tumor cells was enhanced obviously by thermochemotherapy. CONCLUSION: Special high expression of HSP70 in the tumor cells was induced by thermochemotherapy. With the antigen presenting action and other action, HSP70 have special antitumor effect. |
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| Keywords: | thermochemotherapy heat shock protein tumor |
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