A new functional role of HIV-1 integrase during uncoating of the viral core |
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| Authors: | Marisa S. Briones Samson A. Chow |
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| Affiliation: | 1. Department of Molecular and Medical Pharmacology, Molecular Biology Institute, 650 Charles E. Young Dr, CHS 23-133, Los Angeles, CA, 90095, USA
2. UCLA AIDS Institute, UCLA School of Medicine, Los Angeles, CA, 90095, USA
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| Abstract: | An early and critical event of the human immunodeficiency virus type 1 (HIV-1) life cycle is uncoating of the viral core. Uncoating involves the disassembly of HIV-1 capsid (CA). The underlying mechanisms governing uncoating are poorly defined, and the role of viral and host factors in uncoating is not well understood. Cyclophilin A and TRIM5α are two cellular factors that interact with CA in exerting their effects on HIV-1 replication. Here, we review the current understanding of uncoating and the new functional role of HIV-1 IN during uncoating. |
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