| 血清新喋呤、生物喋呤检测及其在尿毒症患者中的应用 |
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| 引用本文： | 丁世家,张名均,邱宗荫. 血清新喋呤、生物喋呤检测及其在尿毒症患者中的应用[J]. 上海医学检验杂志, 2005, 0(6) |
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| 作者姓名： | 丁世家 张名均 邱宗荫 |
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| 作者单位： | 重庆医科大学检验系临床检验诊断学省部共建教育部重点实验室 重庆400016(丁世家，张名均)，重庆医科大学检验系临床检验诊断学省部共建教育部重点实验室 重庆400016(邱宗荫) |
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| 摘 要： | 目的探讨尿毒症患者血清中新喋呤(NP)和生物喋呤(BP)的浓度变化及其临床意义。方法采用反相高效液相色谱-荧光检测(RP-HPLC-FD)的方法,分别测定正常对照组、尿毒症组透析前后血清中的NP、BP浓度,并进行比较。结果尿毒症组血清中的NP、BP浓度和NP/BP比值均显著高于正常组(P<0.01),透析后血清中的NP、BP浓度显著低于透析前血清中NP、BP浓度(P<0.01,P<0.05),而NP/BP比值差异无显著性(P>0.05)。结论在尿毒症患者中,血清中的NP、BP浓度可作为炎性介质激活的灵敏指标,同时可作为判断肾功能好坏的标志物。
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| 关 键 词： | 新喋呤 生物喋呤 尿毒症 |
The application of serum neopterin and biopterin determination in uremia patient |
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| DING Shijia,ZHANG Mingjun,QIU Zongying.Key Laboratory of Laboratory Medicine diagnostics,Ministry of Education,Chongqing University of Medical Sciences,Chongqing ,China. The application of serum neopterin and biopterin determination in uremia patient[J]. Shanghai Journal of Medical Laboratory Sciences, 2005, 0(6) |
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| Authors: | DING Shijia ZHANG Mingjun QIU Zongying.Key Laboratory of Laboratory Medicine diagnostics Ministry of Education Chongqing University of Medical Sciences Chongqing China |
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| Affiliation: | DING Shijia,ZHANG Mingjun,QIU Zongying.Key Laboratory of Laboratory Medicine diagnostics,Ministry of Education,Chongqing University of Medical Sciences,Chongqing 400016,China |
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| Abstract: | Objective To study the changes of serum levels of neopterin(NP) and biopterin(BP) in uremia patient and its clinical significance. Methods Serum NP and BP were determined in uremia patients before and after dialysis and in control group by RP-HPLC-FD method. Results The levels of serum NP,BP and the NP/BP ratio in uremia were significantly higher than that in control group(P<(0.01)).Serum NP and BP in uremia patients increased more significantly before dialysis than that after dialysis.But there was no difference of the ratio NP/BP before dialysis and after dialysis(P>(0.05)). Conclusions Serum NP and BP in uremia patients were sensitive markers of inflammation medium activating and could be used to assess the dysfunction of kidney. |
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| Keywords: | Neopterin Biopterin Uremia |
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