乙肝肝硬化患者血清铁及转铁蛋白检测的临床意义

目的：研究血清铁及转铁蛋白和乙肝肝硬化患者肝功能损害程度的相关性.方法：检测121例乙肝肝硬化患者和60例体检正常者血清铁（Fe）、转铁蛋白（TF）浓度;将肝硬化患者分为A级、B级、C级3组,进行Child-Pugh评分,比较3组患者血清Fe及TF水平,分析血清Fe及TF水平变化与乙肝肝硬化患者肝功能损害程度及肝硬化程度相关性.结果：体检正常者血清铁、转铁蛋白浓度分别为（34.07±13.74） μg/L、（2.74±0.68）ng/L,121例乙肝肝硬化患者血清铁、转铁蛋白浓度分别为（317.28 ±98.42） μg/L、（1.87±0.54） ng/L,两组对比差异有统计学意义（P＜0.01）;Child-PughA级、B级、C级,Child-Pugh评分分别为（4.31 ±1.21）分、（7.87±0.85）分、（11.57±1.23）分,血清铁、转铁蛋白浓度分别为（133.28±42.78） μg/L、（2.11 ±0.37） ng/L、（389.28±101.28） μg/L、（1.95 ±0.51） ng/L、（521.28 ± 112.63） μg/L、（1.67±0.28） ng/L; Child-Pugh B级Fe浓度较A组显著升高,TF浓度较A组显著降低（P＜0.01）,C级Fe浓度较B组显著升高,TF浓度较B组显著降低（P＜0.01）,乙肝肝硬化患者Fe与Child-Pugh分级相关（r=0.824,P＜0.01）,TF与Child-Pugh分级相关（r=-0.728,P＜0.01）.结论：血清Fe及TF与乙肝肝硬化患者肝功能损害程度及肝硬化程度相关.

The Clinical Significance of Detection of Ferritin and Transferrin in Patients with Hepatitis B Induced Cirrhosis

Objective ： To investigate the correlation of ferritin and transferrin with the impairment of hepatic function and the development of cirrhosis in patients with hepatitis B induced cirrhosis. Meth- ods： The levels of ferritin and transferrin were tested in 121 patients with hepatitis B induced cirrhosis and 60 people without any disease. All patients were divided into 3 subgroups according to Child-Pugh~ classification： Child-Pugh A, B and C groups. Comparing levels of ferritin and transferrin of three groups; analyzing the correlation between the changes of ferritin and transferrin levels and the impair- ment of hepatic function and the development of cirrhosis. Results： The levels of ferritin and transfer- rin of people without any disease was （ 34.07±13.74） μg/L and （2174± 0.68 ） ng/L respectively, the levels of ferritin and transferrin of patients with hepatitis B induced cirrhosis was（317.28 ± 98.42）μg/L and （ 1.87 ± 0.54） ng/L, there was statistical significance in the distinction （ P 〈 0. 01 ）. For Child- Pugh A, B and C grade subgroups, respective scores were （4.31±1.21 ）, （7.87± 0.85） and （ 11.57 ±1.23 ）. Levels of ferritin and transferrin were （ 133.28 ±42.78 ） μg/L and （ 2.11 ± 0.37 ） ng/L; （389.28 ±101.28 ） μg/L and （ 1.95 ±0.51 ） ng/L ; （ 521.28± 112.63 ） μg/L and （ 1.67 ± 0. 28）ng/L. The levels of ferritin of group B increased significantly more than group A, its levels of transferrin declined significant more than group A （P 〈 0.01 ） ; the levels of transferrin of group C in- crease more than group B , levels of transferrin of group C declined more than group B （ P 〈 0. 01 ）. There was a correlation between the levels of ferritin and transferrin and the Child-Pugh＇s score （r =O. 824 ,P 〈0.01 ） in patients with hepatitis B induced cirrhosis. Conclusion： The levels of ferritin and transferrin in serum can implicate the impairment of hepatic function and can detect the change of ascites.