血清25羟维生素D3与2型糖尿病周围神经病变的相关性

目的：探讨血清25OH维生素D3（25OHD3）水平与2型糖尿病周围神经病变的关系。方法收集114例2型糖尿病患者，根据临床症状、体征和电生理检查，将患者分为糖尿病合并周围神经病变组（63例）和非糖尿病周围神经病变组（51例），抽取所有受试者空腹静脉血检测血清25OHD3水平，比较2组患者血清25OHD3水平，分析25OHD3与2型糖尿病临床指标间的相关性。结果糖尿病周围神经病变组较非糖尿病周围神经病变组患者维生素D3缺乏发生率分别是79.4％和41.2％，差异有统计学意义（P＜0.01）；糖尿病周围神经病变组患者25OHD3水平低于非糖尿病周围神经病变组，分别为（40.1±12.7）nmol/L与（54.4±18.4）nmol/L，差异有统计学意义（P＜0.01）；25OHD3水平与2型糖尿病患者糖化血红蛋白（HbA1c）及糖尿病病程负相关（P值分别为0.01和0.044）。结论低25OHD3水平是2型糖尿病周围神经病变的危险因素，25OHD3水平与2型糖尿病患者病程和HbA1c相关。

Correlation between serum level of 25-hydroxy vitamin D3 and peripheral neuropathy in patients with type 2 diabetes

Objective To investigate the correlation between serum level of 25-hydroxy vitamin D3 （25OHD3） and peripheral neuropathy in patients with type 2 diabetes .Methods A total of 114 type 2 diabetic patients were enrolled into the study.Among them, 63 patients were diagnosed as diabetic peripheral neuropathy according to clinical symp -toms, signs and electrophysiological sensory testing .The serum levels of 25OHD3 were determined and analysed . Results The frequency of vitamin D deficiency was significantly higher in neuropathic patients than in non -neuropathic patients, the frequencies were 79.4%and 41.2% （P〈0.01）.25OHD3 levels of neuropathic patients were significantly lower than non-neuropathic patients, the values were （40.1 ±12.7 nmol/L vs 54.4 ±18.4 nmol/L） （P〈0.001）.The level of 25OHD3 was associated with HbA1c and the duration of type 2 diabetes （P=0.01 and P=0.044）.Conclusion Low level of 25OHD3 is a risk factor for diabetic neuropathy in type 2 diabetic patients.The level of 25OHD3 is associated with the duration of type 2 diabetes and HbA1c.