Basal ganglia and cerebral cortical distribution of dopamine D1- and D2-receptors in neonatal and adult cat brain |
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| Authors: | E K Richfield D L Debowey J B Penney A B Young |
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| Affiliation: | 1. Instituto de Química de São Carlos, Universidade de São Paulo, Av. Trab. São Carlense, 400 Parque Arnold Schimidt, São Carlos, SP 13566-590, Brazil;2. Escola de Engenharia de Lorena-EEL/USP, Estrada Municipal do Campinho S/N, CEP 12602-810 Lorena, São Paulo, Brazil;3. Instituto Tecnológico de Aeronáutica-ITA/CTA, Praça Mal. Eduardo Gomes 50, CEP 12228-900 São José dos Campos, São Paulo, Brazil;4. School of Materials Science and Engineering, China University of Petroleum, QingDao 266580, China |
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| Abstract: | Quantitative receptor autoradiography was performed on neonatal and adult cat brains. Serial sections through the basal ganglia were assayed for D1- and D2-dopamine receptors and acetylcholinesterase (AChE) staining. The neonatal basal ganglia revealed patches of increased D1-receptor density that frequently overlapped with patches of increased AChE staining, while the D2-receptor distribution was more homogeneous. The adult basal ganglia revealed a mild amount of heterogeneity for both the D1- and D2-receptors, varying from 10 to 25%, with little correspondence to the marked heterogeneity seen with AChE staining. A distinct laminar distribution of the D1-receptor, without significant D2 binding, was seen in the cerebral cortex. |
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