| 脑利钠肽与小儿心血管疾病 |
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| 引用本文： | 张志玲,林丽星,杨梅.脑利钠肽与小儿心血管疾病[J].兰州医学院学报,2009,35(3):103-108. |
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| 作者姓名： | 张志玲 林丽星 杨梅 |
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| 作者单位： | 兰州大学第一医院儿科,甘肃,兰州,730000 |
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| 基金项目： | 兰州大学医学科研基金 |
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| 摘 要： | 脑利钠肽（BNP）是一种主要来源于心室的心脏内分泌激素,在脑利钠肽前体分泌过程中或进入血液后分解为无生物活性的N端片段（NT-proBNP）和具有生物活性的BNP。BNP具有利尿、利钠、扩张血管和拮抗肾素-血管紧张素-醛固酮系统等多种生物学作用。许多研究表明心血管疾病患儿的血浆NT-proBNP和BNP水平升高,且NT-proBNP和BNP反映心室功能,因此可应用于心血管疾病患儿的诊断和评估。
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| 关 键 词： | 脑利钠肽 心血管疾病 儿童 |
Brain natriuretic peptide in children's cardiovascular diseases |
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| ZHANG Zhi-ling,LIN Li-xing,YANG Mei.Brain natriuretic peptide in children's cardiovascular diseases[J].Journal of Lanzhou Medical College,2009,35(3):103-108. |
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| Authors: | ZHANG Zhi-ling LIN Li-xing YANG Mei |
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| Institution: | (Department of Pediatrics, First Hospital of Lanzhou University, Lanzhou 730000, China) |
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| Abstract: | Brain natriuretic peptide （BNP） is a cardiac hormone mainly secreted by myocytes in the ventricular wall. It is synthesized as an inactive prohormone that is split into inactive N- terminal fragment （NT-proBNP） and active hormone BNP. BNP has a number of systemic effects, including increases in urinary volume and sodium output, vascular dilation and inhibition of the renin-angiotensin-aldosterone system. The increased levels of NT-proBNP and BNP have been reported in children＇s cardiovascular diseases in numerous studies and can reflect cardiac function. Therefore, NT-proBNP and BNP can be used to diagnose and evaluate children＇s cardiovascular diseases. |
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| Keywords: | brain natriuretic peptide cardiovascular disease children |
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