| CTLA-4与超抗原对SEA诱导T细胞无能的关联研究 |
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| 引用本文： | 许桂莲,朱锡华,杨劲,黄云辉. CTLA-4与超抗原对SEA诱导T细胞无能的关联研究[J]. 现代免疫学, 2002, 22(5): 319-321 |
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| 作者姓名： | 许桂莲 朱锡华 杨劲 黄云辉 |
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| 作者单位： | 第三军医大学全军免疫学研究所,重庆,400038 |
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| 基金项目： | 全军“九五”医药卫生科研重点基金资助项目(No 96Z0 39) |
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| 摘 要： | 在建立超抗原SEA诱导T细胞无能的体外模型基础上 ,观察了无能T细胞受SEA刺激时共刺激分子CD2 8和CTLA 4的表达。结果发现 ,与活化组相比 ,在SEA加入后的不同时相点无能T细胞上CD2 8的表达都是正常的 ,而CTLA 4分子在SEA加入的第 60小时细胞表面有高水平的表达。这些结果表明 ,超抗原SEA诱导的这种无能状态与CTLA 4所介导的抑制作用增强有关
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| 关 键 词： | 共刺激分子 CD28/CTLA-4 无能 超抗原SEA |
| 文章编号： | 1001-2478(2002)05-0319-03 |
| 修稿时间： | 2001-12-06 |
Study on the Relationship Between Costimulatory Molecules CD28/CTLA-4 and TLymphocytes Anergy Induced by Superantigen SEA |
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| XU Gui lian,ZHU Xi hua,YANG Jin,HUANG Yun hui. Study on the Relationship Between Costimulatory Molecules CD28/CTLA-4 and TLymphocytes Anergy Induced by Superantigen SEA[J]. Current Immunology, 2002, 22(5): 319-321 |
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| Authors: | XU Gui lian ZHU Xi hua YANG Jin HUANG Yun hui |
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| Abstract: | The expression of costimulatory molecules CD28 and CTLA 4 in anergic T cells was determinated by FACS after establishing a T cell anergy model induced by superantigen SEA It was found that the expression of CD28 was normal at different times of SEA stimulation,but the level of CTLA 4 expression was markedly enhanced at 60 h after the addition of SEA,suggesting that the enhanced cell surface expression of CTLA 4 is likely responsible for the induction and maintenance of T cells anergy induced by superantigen SEA |
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| Keywords: | costimulatory molecules CD28/CTLA 4 anergy superantigen SEA |
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