| 电压门控性钾通道与三叉神经痛 |
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| 引用本文： | 李娜,马蓓,邓小明.电压门控性钾通道与三叉神经痛[J].第二军医大学学报,2009,30(4):432-436. |
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| 作者姓名： | 李娜 马蓓 邓小明 |
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| 作者单位： | 1. 第二军医大学长海医院麻醉科,上海,200433
2. 第二军医大学基础部生理学教研室,上海,200433 |
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| 基金项目： | 上海市科学技术委员会基金(08JC1405400). |
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| 摘 要： | 电压门控性钾通道维持神经元静息膜电位，参与细胞兴奋性的改变。在三叉神经痛发病过程中，三叉神经节神经元作为初级感觉神经元，在痛觉的传导和传递过程中起重要作用。电压门控性钾通道的多种类型在三叉神经节神经元中均有表达，激活时产生不同类型的钾电流。电压门控性钾通道功能的改变，及其与多种神经递质、炎性介质和受体间的相互作用，在三叉神经痛的发病过程中起到了重要作用。
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| 关 键 词： | 电压门控钾通道 三叉神经痛 三叉神经节 背根神经节 受体 |
| 收稿时间： | 2008/11/20 0:00:00 |
| 修稿时间： | 2008/12/17 0:00:00 |
Voltage-gated potassium channels and trigeminal neuralgia |
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| LI N,MA Bei,DENG Xiao-ming.Voltage-gated potassium channels and trigeminal neuralgia[J].Academic Journal of Second Military Medical University,2009,30(4):432-436. |
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| Authors: | LI N MA Bei DENG Xiao-ming |
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| Institution: | 1.Department of Anaesthiology, Changhai Hospital, Second Military Medical University, Shanghai 200433,China;2.Department of Physiology, College of Basic Medical Sciences,Second Military Medical University, Shanghai 200433 |
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| Abstract: | Voltage-gated potassium channels regulate cell membrane potential and excitability in neurons. Trigeminal ganglion as a primary sensory neuron plays an important role in the pain transduction and transmission of trigeminal neuralgia. Trigeminal ganglion neurons express many subtypes of voltage-gated potassium channels and they can evoke different type of K+ current when activated. The alteration of voltage-gated potassium channels and their interaction with neurotransmitters, inflammatory cytokines and receptors play important roles in the development of trigeminal neuralgia. |
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| Keywords: | voltage-gated potassium channels trigeminal neuralgia trigeminal ganglion dorgalroot ganglia receptors |
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