cofilin1在胃癌组织中表达的临床病理意义

目的检测胃癌组织中cofilin1蛋白的表达水平，探讨cofilin1蛋白在胃癌发生、发展中的作用。方法应用组织芯片与免疫组织化学SP法检测cofilin1在正常胃黏膜、上皮内瘤变和胃癌组织中的表达。结果cofilin1在正常组织、上皮内瘤变与胃癌中表达呈递增趋势（P<0.05）；弥漫型胃癌cofilin1阳性率显著高于肠型胃癌（P<0.05）。胃癌中瘤直径≤3.0 cm的cofilin1的表达明显低于＞3.0 cm的表达（P<0.05）。淋巴结转移组表达明显高于未转移组（P<0.05）。TNM分期Ⅲ、Ⅳ期表达明显高于Ⅰ、Ⅱ期（P<0.05）。cofilin1表达与患者性别差异无统计学意义（P>0.05）。结论cofilin1与胃癌肿瘤大小、分化程度、淋巴结转移、临床分期密切相关，且与胃癌进展及预后密切相关，可能是胃癌侵袭转移的重要生物标志。

Clinicopathological Significance of cofilin1 in Gastric Cancer Tissues

Objective To investigate the expression of cofilin1 in gastric cancer and its clinicopathological significance.Methods Tissue chip and immunohistochemistry(SP method)were used to detect the expression of cofilin1 in 75 cases of gastric cancer,30 cases of normal tissue and 23 cases of intraepithelial neoplasia.To analyze its relation to clinicopathological features like clinic stage of gastric cancer,lymph node metastasis and so on.Results The expression positive rate of cofilin1 in normal tissue,intraepithelial neoplasia and gastric carcinoma showed an increasing trend(P<0.05)and diffuse gastric cancer positive rate was significantly higher than that of intestinal type gastric cancer(P<0.05).The expression positive rate of cofilin1 in gastric tumor smaller than 3.0 cm was lower than that in the group bigger than 3.0 cm(P<0.05).The expression positive rate of lymph node metastasis group was significantly higher than the group without metastasis(P<0.05).The expression positive rate of the histological grade Ⅲ and Ⅳ of TNM were significantly higher than that of stage ⅠandⅡ(P<0.05).There was no significant difference between the group with different gender(P>0.05).Conclusion The expression of cofilin1 had close correlation with the degree of differentiation,tumor volume,lymph node metastasis and TNM staging in gastric cancer.cofilin1 was closely related to the development and prognosis,and it might be regarded as an important biomarker in gastric cancer.