甲状腺乳头状癌组织中SOX2和 CyclinD1的表达及相关性

目的：探讨甲状腺乳头状癌组织中性别决定区 Y 框蛋白（SOX2）和细胞周期素 D1（CyclinD1）的表达及相关性。方法采用免疫组化 S-P 法检测100例甲状腺乳头状癌和50例癌旁正常甲状腺组织中 SOX2和 CyclinD1的表达，并分析两者与甲状腺乳头状癌患者临床病理参数的关系。结果甲状腺乳头状癌组织中 SOX2和 CyclinD1的阳性率分别为80.0%和73.0%，均高于癌旁正常甲状腺组织的10.0%和4.0%，差异有统计学意义（P <0.05）。甲状腺乳头状癌组织中 SOX2和 CyclinD1的表达与其临床分期、淋巴结转移关系密切（P <0.05）。甲状腺乳头状癌组织中 SOX2和 CyclinD1的表达呈正相关（r =0.597，P <0.05）。结论甲状腺乳头状癌组织中 SOX2和 CyclinD1存在表达，两者可能共同参与了甲状腺乳头状癌的疾病进展。

Expressions of SOX2 and CyclinD1 in the Papillary Thyroid Carcinoma

Objective To investigate the expressions of sex determining region Y-box(SOX2)and CyclinD1 in the patients with papillary thyroid carcinoma and the correlation. Methods Immunohistochemical S-P method was used to detect the expressions of SOX2 and CyclinD1 in the 100 patients with papillary thyroid carcinoma and 50 pa-tients with paraneoplastic normal thyroid tissues,their relationship with clinicopathological parameters were ana-lyzed. Results The positive rates of SOX2 and CyclinD1 in the papillary thyroid carcinoma were 80. 0% and 73. 0% ,and were 10. 0% and 4. 0% in the paraneoplastic normal thyroid tissues(P < 0. 05). The expressions of SOX2 and CyclinD1 in the papillary thyroid carcinoma were related with clinical stage and lymph node metastasis (P < 0. 05). In the papillary thyroid carcinoma,the expression of SOX2 was positively related with CyclinD1(r =0. 597,P < 0. 05). Conclusion high expressions of SOX2 and CyclinD1 are observed in the papillary thyroid carci-noma,and may be related to the development of papillary thyroid carcinoma.