冠心病患者 PCI 术后心肌纤维化与心脏功能的变化 |
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引用本文: | 贺鹏辉,王西辉,解飞. 冠心病患者 PCI 术后心肌纤维化与心脏功能的变化[J]. 医学临床研究, 2016, 0(7). DOI: 10.3969/j.issn.1671-7171.2016.07.028 |
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作者姓名: | 贺鹏辉 王西辉 解飞 |
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作者单位: | 西安医学院第二附属医院心内科,陕西 西安,710038 |
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摘 要: | 【目的】探讨冠心病患者PCI术后心肌纤维化与心脏功能的变化。【方法】选取自2013年6月至2015年1月在本院接受经皮冠状动脉介入治疗(PCI)的150例冠心病患者,观察患者在PCI手术前及术后3个月、6个月、12个月的血清Ⅰ、Ⅲ型前胶原(PCⅠ、PCⅢ)、层黏蛋白(LN)、透明质酸(HA)水平的变化以及左心室射血分数(LVEF)、左心室舒张末期内径(LVEDD)的改善情况。【结果】PCI手术后,冠心病患者血清PCⅠ、PCⅢ、LN、HA水平较术前明显降低,LVEF较术前明显增加,LVEDD较术前明显降低,差异均具有统计学意义(均P<00.5)。【结论】PCI手术能够明显改善冠心病患者心肌纤维化及心脏功能。
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关 键 词: | 冠心病 血管成形术 ,经腔 ,经皮冠状动脉 心肌 纤维化 心脏功能试验 |
Changes of Myocardial Fibrosis and Cardiac Function in Patients with Coronary Heart Disease after Percutaneous Coronary Intervention |
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Abstract: | [Objective] To investigate the changes of myocardial fibrosis and cardiac function in patients with coronary heart disease after percutaneous coronary intervention (PCI) .[Methods]A total of 150 patients who un‐derwent PCI at our hospital from June 2013 to January 2015 were observed .Before PCI and at the third month , sixth month ,and twelfth month post‐operation ,the changes of serum procollagen Ⅰ ,Ⅲ (PCⅠ ,PC Ⅲ) ,laminin (LN) ,and hyaluronic acid (HA) level were collected .Left ventricular ejection fraction (LVEF) and left ventricu‐lar end‐diastolic diameter (LVEDD) were detected as well .[Results]After PCI surgery ,the PCⅠ ,PC Ⅲ ,LN , HA ,LVEDD were lower than before surgery ,while LVEF was higher;the differences were statistically signifi‐cant ( P <0 0.5) .[Conclusion]PCI surgery can significantly improve cardiac function and myocardial fibrosis in patients with coronary heart disease . |
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Keywords: | Coronary Disease Angioplasty,Transluminal,Percutaneous Coronary Myocardium Fi-brosis Heart Function Tests |
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