63例卵巢浆液性癌的MDACC分级及临床病理意义

【目的】探讨卵巢浆液性癌的MDACC分级及临床病理意义。【方法】回顾性分析本院63例卵巢浆液性癌患者的病理资料，对其进行MDACC分级及传统WHO分级对比，所有患者行p53蛋白免疫组化染色，总结其临床病理特点并比较两种分级的优缺点。【方法】MDACC分级法中低级别相当于传统WHO分级法中的Ⅰ级，高级别组相当于Ⅱ级和Ⅲ级；MDACC分级中低级别组与高级别组患者的平均年龄、平均肿瘤直径、发生范围比较差异无统计学意义（P〉0．05）；MDACC分级中高级别组的癌症患者临床分期更高，无病生存时间及生存时间明显短于低级别组，5年生存例数少于低级别组，p53蛋白突变型表达更多，差异均具有统计学意义（P〈0．05）。【结论】MDACC分级与分子生物学表型及发病学说有非常好的契合，简便易掌握，且对预后有一定的指导意义。

Pathological Effects of (MDACC)Classification of 63 Cases of Ovarian Serous Carcinoma

Obj ective]To investigate the MDACC classification of ovarian serous carcinoma and its clinical pathological significance.Methods]Pathological data of 63 cases with ovarian serous carcinoma patients in our hos-pital were retrospectively analyzed,comparison of MDACC grading and traditional WHO classification were con-ducted.P5 3 immunohistochemical staining was performed in all patients,and their clinicopathological features were summarized and the advantages and disadvantages of the two grades were compared.Results]The low grade level of MDACC classification is equivalent to the Ⅰclassification of traditional WHO,the high grade is equivalent to grade Ⅱ and Ⅲ;In MDACC grading,the average age,the mean tumor diameter and the range of occurrence showed no difference of statistical significance in the low level group and the senior group of patients(P >0.05).In MDACC grading,clinical stage of cancer patients of high level group was higher,no disease survival duration and survival time was significantly shorter than those in the low grade group,and 5-year survival of patients was less than the number of low-level group,with more p5 3 mutant expression,the difference has statistical significance (P <0.05).Conclusion]MDACC classification has a very good fit with molecular biological phenotype and patho-genesis theory,it is simple and easy to grasp,and has a certain guiding significance for the prognosis.