结肠黏液腺癌临床病理特征分析

目的：探讨结肠黏液腺癌的临床病理特征及预后特点。方法回顾性分析672例初治的接受根治性手术的结肠癌患者，其中黏液腺癌为41例，非黏液腺癌为631例，比较两者临床病理特征和复发方式。结果黏液腺癌患者比非黏液腺癌患者更年轻（<50岁比例：48.8豫 vs 31.4豫，P <0.05），肿瘤直径更大（6.0 cm vs 4.5 cm，P <0.05），更多位于右半结肠（右半结肠比例：44.0豫 vs 17.3豫，P <0.05）和病理 T 分期更高（T3、T4比例：90.2豫 vs 72.7豫，P <0.05），3 a 生存率更短（39.2豫 vs 68.5豫，P <0.05）。复发情况中，黏液腺癌腹膜转移率比非黏液腺癌更高（57.1豫 vs 1.5豫，P <0.05）。结论与非黏液腺癌比较，结肠黏液腺癌发病年龄更年轻，更多处于晚期和右半结肠，腹膜转移可能性更大，治疗预后更差，提示结肠黏液腺癌患者需要特异的治疗方案。

Pathological Features of Colonic Mucinous Adenocarcinoma

Objective To investigate clinicopathological characteristics and prognosis of colonic mucinous adeno-carcinoma. Methods A retrospective study was performed about 672 newly diagnosed patients(41 patients were colonic mucinous adenocarcinoma and 631 were nonmucinous adenocarcinoma). The clinicopathological characteris-tics and recurrence were studied. Results The patients with colonic mucinous adenocarcinoma were younger than the patients with nonmucinous adenocarcinoma(Age < 50 years old,48. 8% vs 31. 4% ,P < 0. 05),had larger tumor diameter(6. 0 cm vs 4. 5 cm,P < 0. 05),were more right-sided colon cancer(44. 0% vs 17. 3% ,P <0. 001),had higher pathologic T3 and T4 stage(90. 2% vs 72. 7% ,P < 0. 05),had lower three year survival rate (39. 2% vs 68. 5% ,P < 0. 05). More patients with colonic mucinous adenocarcinoma suffered peritoneal metastasis compared with the patients with nonmucinous adenocarcinoma(57. 1% vs 1. 5% ,P < 0. 05). Conclusion Com-pared with patients with nonmucinous adenocarcinoma,patients with colonic mucinous adenocarcinoma are younger, and found at more advanced stage;colonic mucinous adenocarcinoma is mainly located at the right side of the co-lon;the probability of peritoneal metastasis is higher;colonic mucinous adenocarcinoma indicates a worse progno-sis. The biological behavior of colonic mucinous adenocarcinoma is different from nonmucinous adenocarcinoma,so patients with colonic mucinous adenocarcinoma require more specific therapy.