可溶性血管内皮钙粘素对脑胶质瘤患者预后的影响

【目的】探讨可溶性血管内皮钙粘素（VE‐cadherin）对脑胶质瘤患者预后的影响。【方法】选取2013年1月至2014年10月本院收治的59例脑胶质瘤患者，对患者临床资料进行单因素分析和多因素 Lo‐gistic 回归分析，根据 VE‐cadherin 水平将脑胶质瘤患者分为 A 组（VE‐cadherin 水平＜800 ng／mL ，n ＝23）、B组（VE‐cadherin 水平为800～1500 ng／mL ，n ＝25）、C 组（VE‐cadherin 水平＞1500 ng／mL ，n ＝11），比较三组患者1年生存率。【结果】年龄、肿瘤部位、术前 KPS 评分、病理分级、肿瘤直径、术前癫痫、术前水肿、肿瘤囊变、VE‐cadherin 水平对脑胶质瘤患者预后具有显著影响，差异均具有统计学意义（均 P ＜0．05）。对有统计学意义的上述因素进行多因素 Logistic 回归分析，结果显示年龄、术前 KPS 评分、病理分级、肿瘤直径、放疗剂量、VE‐cadherin 是影响颅脑胶质瘤患者预后的独立危险因素（P ＜0．05）。 A 组、B 组、C 组患者的1年生存率分别为95．65％（22／23）、80．00％（20／25）、54．55％（6／11），A 组生存率显著高于 B 组、C 组，差异具有统计学意义（χ2＝5．976，P ＝0．015＜0．05）。【结论】可溶性 VE‐cadherin 水平是影响颅脑胶质瘤患者生存率的独立危险因素，对预测患者术后预后有重要的临床意义。

Effect of Soluble Vascular Endothelial Cadherin on Prognosis of Patients with Brain Glioma

Objective]To investigate the effect of soluble vascular endothelial cadherin on the prognosis of patients with brain glioma .Methods]The clinical data of 59 patients with brain glioma who were admitted to our hospital from January 2013 to October 2014 were selected and analyzed by single factor analysis and multi‐ple factor Logistic regression analysis .According to the level of VE‐cadherin in glioma ,patients were divided into group A (VE‐cadherin < 800 ng/mL ,n = 23) ,group B (VE‐cadherin 800 ~ 1500 ng/mL n = 25 level , group C (VE‐cadherin > 1500 ng /mL ,n = 11) ,1 year survival rate of the three groups of patients was com‐pared with .Results]Factors of age ,tumor location ,preoperative KPS score ,pathological grade ,diameter of tumor ,preoperative epilepsy ,preoperative edema ,cystic become ,E‐cadherin levels were correlated with the prognosis of patients with brain glioma ,the difference was statistically significant (mean P < 0 .05) .By multi‐variate Logistic regression analysis of the above mentioned significant factors ,the indexes of age ,preoperative KPS score ,pathological grade ,tumor diameter ,radiotherapy dose and VE‐cadherin were independent prog‐nostic risk factors in patients with brain glioma ( P < 0 .05) .1 year survival rates of the Group A ,Group B and Group C were 95 .65% (22/23) ,80% (20/25) ,54 .55% (6/11) ;the survival rate of the Group A was significantly higher than that of the Group B and the Group C ,the difference was statistically significant (χ2 =5 .976 ,P = 0 .015 < 0 .05) .Conclusion]The level of soluble vascular endothelial cadherin is independent risk factor that affects the survival of patients with brain glioma ,it has important clinical significance to predict the prognosis of patients after operation .