不同氧流量雾化吸入治疗对老年COPD患者促排痰的效果比较

【目的】比较不同氧流量雾化吸入治疗对老年慢性阻塞性肺疾病（COPD）患者促排痰的效果。【方法】选取本院2014年3月至2015年12月收治的99例需进行雾化吸入治疗的老年COPD患者作为研究对象，采用随机数字表法分为高氧流量、中氧流量、低氧流量三组，每组各33例。在相同雾化风力、抗菌药物方案治疗基础上分别给予不同氧流量进行雾化吸入，对比三组患者治疗前后效果及排痰量的变化情况。【结果】雾化治疗7 d后三组患者的第一秒用力呼气容积（FEV1）、动脉血氧分压（PaO2）、动脉二氧化碳分压（PaCO2）较治疗前均显著的改善（ P ＜00．5），高氧流量组改善效果更佳（ P ＜00．5）；三组患者在雾化治疗后d1、d3排痰量均显著增加，d3达到排痰高峰，高氧流量组在治疗d1、d3、d5时的排痰量显著高于中、低氧流量组且差异具有统计学意义（P ＜00．5），治疗d7高氧流量组的排痰量显著的减少（P ＜00．5）；高氧流量组的肺部啰音消失时间、体温恢复正常时间、血常规恢复时间、住院时间均显著的少于中、低氧流量组，且差异具有统计学意义（ P ＜0．05）。【结论】高氧流量雾化吸入治疗对老年COPD患者有利于患者痰液排出，有效改善患者肺功能、血气指标，提高治疗效果。

Comparison of the Effect of Different Oxygen Flow Rates of Aerosol Inhalation in the Treatment of Elderly Patients with Chronic Obstructive Pulmonary Disease

[Objective] To analyze the difference of the effect of different atomization inhalation therapy on the promotion of sputum elimination in elderly patients with chronic obstructive pulmonary disease (COPD) .[Methods]Ninety‐nine cases of elderly patients with COPD were selected as the research object and divided into three groups of high ,medium ,and low volume of oxygen flow inhalation according to the random number table method ,with thirty‐three patients in each group .The compari‐sons of lung functional index and sputum elimination among groups were performed based on the same condition of air flow and antibiotics in the automation inhalation treatment[.Results]The PaO2 ,PaCO2 ,and FEV1(forced expiratory volume) at 7d af‐ter treatment levels in the three groups were significantly improved ,and the effects on patients in the high oxygen volume group were significantly higher than those of patients in the medium and low oxygen volume groups ( P <0 0.5) .At 1d and 3d after treatment ,sputum discharge levels of patients in all groups were significantly increased;all reached their peaks at 3d ..At 1d ,3d ,and 5d after treatment ,the sputum expectoration levels of patients in the high oxygen volume group were significantly higher than those of patients in the other two groups ( P <0 0.5) .At 7d after treatment ,the amount of sputum elimination in patients of the high oxygen volume group was significantly reduced ( P <0 0.5) .Time periods for disappearance of pulmonary rales ,time frame for body temperature and blood to return to normal ,and length of hospital stay were significantly lower in patients of the high oxygen volume group compared to those of the other two groups ;the differences were statistically signifi‐cant ( P <0 0.5) .[Conclusion]High amount of atomization inhalation in the treatment of elderly patients with COPD has posi‐tive effects on sputum discharge ,thus improving the pulmonary function ,blood gas index ,and therapeutic effect .