乌司他丁对重症烧伤患者血小板水平及凝血功能的影响

目的]探讨乌司他丁对重症烧伤患者血小板水平及凝血功能的影响.方法]选择本院2013年1月至2014年1月就诊的重症烧伤患者25例,将其随机分为观察组(n=13)和对照组(n=12),对照组给予常规治疗,观察组患者在常规治疗的基础上静脉注射乌司他丁,连续用药7 d.观察治疗前及治疗后d1、d3、d7血小板计数(PLT)、血小板粘附率(PAR)、血小板分布宽度(PDW)及血小板平均容积(MPV)的变化,并检测两组患者治疗前及治疗后凝血酶原时间(PT)、凝血酶时间(TT)、部分凝血活酶时间(APTT)、血浆纤维蛋白原(FIB)及血浆-D二聚体(DD)水平.结果]观察组治愈率显著高于对照组,创面脓毒症、创面感染、电解质紊乱、器官功能障碍发生率均低于对照组,差异均具有统计学意义(均P<0.05);与治疗前比较,两组患者治疗后d1、d3、d7血小板PLT、PAR、MPV、PDW水平显著高于治疗前,差异具有统计学意义(P<0.05);两组患者PT、APTT治疗后较治疗前均明显缩短,FIB、DD水平明显降低,差异均具有统计学意义(均P<0.05).结论]重症烧伤患者应用乌司他丁对凝血功能具有一定的改善作用,对其病情变化、并发症、器官功能均有较好改善作用.

Effects of Ulinastatin on Platelet and Blood Coagulation Function in Severe Burn Patients

Objective]To observe the effects of ulinastatin on platelet and blood coagulation function in severe burn patients.Methods]Twenty-five patients with severe burns treated in our hospital from January 2013 to January 2014 were randomly divided into experimental group (n=13)and control group (n=12).Routine treatment were conducted for the control group,whereas the experimental group were given an inj ection of ulinastatin with continuous administra-tion 7 d based on the above conventional treatment scheme.Changes of platelet count (PLT),platelet adhesion rate (PAR),platelet distribution width (PDW)and mean platelet volume (MPV)of the experimental group were observed be-fore and after treatment D1 D3 D7 .Prothrombin time (PT),thrombin time (TT),activated partial thromboplastin time (APTT),plasma fibrinogen original (FIB)and plasma-two D dimer (DD)levels of two groups of patients were meas-ured before and after treatment.Results]The cure rate of the observation group was significantly higher than that of the control group:wound sepsis,wound infection,electrolyte disorders and organ dysfunction rate were lower than those of the control group,the differences were statistically significant (P<0.05).PT and APTT of the two groups were significant-ly decreased after and before treatment.FIB and DD were significantly decreased,the difference was statistically significant (P <0.05).Conclusion]Ulinastatin administrated on severe burn patients have a positive effect on blood coagulation function,and has a good efficacy on their illness,complications and organ function.