血清ADAM 12-S在孕早期孕妇异位妊娠中的诊断价值

[目的]探讨血清解整合素-金属蛋白酶(ADAM12-S)在孕早期孕妇异位妊娠中的诊断价值.[方法]选取异位妊娠孕妇92例(异位妊娠组)和106例正常单胎妊娠孕妇(正常妊娠组),采用时间分辨荧光免疫分析法检测血清ADAM 12-S水平,分析异位妊娠的工作曲线(ROC).[结果]在不同孕周,正常妊娠组孕妇ADAM 12-S水平均显著高于异位妊娠组(P<0.05);正常妊娠组孕妇ADAM 12-S水平随孕周呈二次函数式上升趋势(P<0.05);在ROC曲线中当ADAM 12-S水平为1.565μg/L时,其诊断异位妊娠的灵敏度为99.06%,特异度为100.00%.[结论]ADAM 12-S可作为诊断异位妊娠的生物标志物,具有较高的灵敏度和特异度,值得在临床上推广应用.

Value of Serum ADAM 12-S on the Early Diagnosis of Ectopic Pregnancy

[Objective]To investigate and explore the clinical value of serum ADAM 12-S on the early di-agnosis of ectopic pregnancy.[Methods]The 106 normal singleton pregnancy women (the normal group)and 92 ectopic pregnancy women(the ectopic group)treated in our hospital were selected.Time resolved fluores-cence immunoassay was used to detect serum ADAM 12-S level and to analyze the working curve (ROC)of ectopic pregnancy.[Results]In different pregnancy weeks,ADAM 12-S levels in the normal pregnant group was much higher than that of the ectopic pregnancy group (P <0.05);ADAM 12-S level of normal pregnant women showed a quadratic functional rise along with the gestational age (P <0.05)The sensitivity of the di-agnosis of ectopic pregnancy was 99.06%,the specificity was 100% when the ADAM 12-S level was 1.565 g/L in the ROC curve.[Conclusion]ADAM 12-S can be used as a biomarker for diagnosis of ectopic pregnancy, with high sensitivity and specificity,it is worthy of popularization and application in clinic.