Association light chain deposition disease (LCDD) and amyloidosis. One case |
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Authors: | C Hofmann-Guilaine D Nochy C Jacquot V Tricottet J Bariety J P Camilleri |
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Affiliation: | Service d''Anatomie et de Cytologie Pathologique and Groupe de Recherche sur la Pathologie Rénale et Vasculaire INSERM U 28, CNRS ERA 48, Hôpital Broussais, Paris, France |
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Abstract: | Up to now, light chain deposition disease (L.C.D.D.) and amyloidosis have been shown to occur in different individuals. A case of association is described in a 76 year old man with terminal renal failure and normal size kidneys. Percutaneous renal biopsy showed glomerular and peritubular fixation of labeled antikappa light chain serum. Stains for amyloidosis were positive in small vessels. Kappa free chains were found in both serum and urine and the bone marrow showed predominantly kappa-containing plasma cells. By electron microscopy both electron-dense granular deposits and amyloid like fibrils were found in the wall of arterioles and small arteries. |
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Keywords: | Muliple myeloma Light chain deposition Amyloidosis |
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