| 互隔交链孢霉毒素AME和AOH合成物的诱变性 |
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| 引用本文： | 苏堤,李玉华,阮丽荣,徐友梅. 互隔交链孢霉毒素AME和AOH合成物的诱变性[J]. 郑州大学学报(医学版), 1991, 0(3) |
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| 作者姓名： | 苏堤 李玉华 阮丽荣 徐友梅 |
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| 作者单位： | 河南医科大学微生物学教研室(苏堤，李玉华，阮丽荣)，河南医科大学微生物学教研室(徐友梅) |
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| 摘 要： | 对互隔交链孢霉毒素——交链孢酚单甲醚(Alternariol monomethyl ether,AME)和交链孢酚(Alternariol.AOH)的合成物进行了细菌回复突变试验.检测其诱变性。结果表明:AME和AOH提取物和合成物(不加S_9)对鼠伤寒沙门氏菌TA102菌株和大肠菌ND-160菌株.均显示致突变效应.而后者对AME和AOH更为敏感。用相同剂量.AOH对大肠杆菌ND—160菌株诱变比值(MR)比AME高2～7倍,表明AOH的诱变性更强。合成物与提取物相比,合成物的诱变作用较强。
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| 关 键 词： | 交链孢酚单甲醚(AME) 交链孢酚(AOH) 诱变性 细菌回复突变试验 鼠伤寒沙门氏菌 大肠杆菌 |
Mutagenicity of synthetical mycotoxin of AME and AOH of AI-ternaria alternata |
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| Su Di,Li Yuhua,Ruan Lirong,Xu Youmei. Mutagenicity of synthetical mycotoxin of AME and AOH of AI-ternaria alternata[J]. Journal of Zhengzhou University: Med Sci, 1991, 0(3) |
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| Authors: | Su Di Li Yuhua Ruan Lirong Xu Youmei |
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| Affiliation: | Su Di;Li Yuhua;Ruan Lirong;Xu Youmei Department of Microbiology |
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| Abstract: | Mutagenicity of synthetical and extractive AME (alternariol monomethyl ether) and AOH (al-ternariol)of Alternaria alternata was studied with reverse mutation test of bacteria. The results showedthat synthetical and extractive AME and AOH had mutagenic effects on Salmonella typhimurium TA102 and E. Coli ND--160 strains(without S_9),and the latter was more sensitive. With the same doses,the rate of mutation of E. coli ND--160 with AOH was 2--7 times higher than that with AME. Themutagenic effect of the synthetic compound was stronger than that of the extract. |
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| Keywords: | mutagenicity alternariol monomethyl ether alternariol reverse mutation test of bacteria S. typhimurium E. coli |
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