Significant immunomodulatory properties of curcumin in patients with osteoarthritis; a successful clinical trial in Iran |
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| Affiliation: | 1. Nanotechnology Research Center, BuAli Research Institute, Student Research Committee, Department of Medical Biotechnology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran;2. Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran;3. Division of Pharmaceutical Sciences, School of Pharmacy, University of Missouri-Kansas City, Kansas City, MO, USA;4. Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran;5. School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran;1. Department of Kinesiology and Health Promotion, University of Kentucky, Lexington, Kentucky 40506, USA;2. Akay Flavours & Aromatics Pvt. Ltd., R&D Centre, Ambunadu, Malayidamthuruthu P.O., Cochin 683561, India;3. Department of Biostatistics, University of Kentucky, Lexington, Kentucky 40536, USA;4. Human Performance Laboratory, Ball State University, Muncie, Indiana 47306, USA;1. Cellular and Molecular Research Center, Research Institute for Health Development, Kurdistan University of Medical Sciences, Sanandaj, Iran;2. Immunology Research Center, Inflammation and Inflammatory Diseases Division, Department of Immunology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran;3. Department of Academic Diabetes, Endocrinology and Metabolism, Hull York Medical School, University of Hull, Hull HU3 2JZ, UK;4. Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran;5. Neurogenic Inflammation Research Center, Mashhad University of Medical Sciences, Mashhad, Iran;6. School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran. |
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| Abstract: | Osteoarthritis (OA) routinely is known as a multifactorial degenerative joint disease. This trial aimed to assess the curcumin (an active element of turmeric) effects on the immune responses in OA patients. Thirty patients were selected according to the American College of Rheumatology (ACR) criteria and Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) and equally divided into the two groups; intervention (received Sinacurcumin® 80 mg daily) and placebo, followed for 3 months. In the intervention group, our data showed a noticeably decrease in Visual Analog Score (VAS), C-reactive protein (CRP), CD4+ and CD8+ T cells, Th17 cells and B cells frequency. Additionally, Treg cells indicated a significant increase and Treg/Th17 cells ratio showed a meaningfully shifted toward Treg lymphocytes. In conclusion, our data indicated that clinical manifestation was ameliorated considerably following the administration of curcumin. Moreover, our data demonstrated the immunomodulatory effects of curcumin in OA patients. |
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| Keywords: | Osteoarthritis Curcumin Clinical trial Th17 Treg BAFF receptors |
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