| Pathophysiological changes and mechanism of cerebral pathological after high-energy firearm wound in extremities of dogs |
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| 作者姓名： | 封亚平 章翔 费舟 吴景文 武弋 梁景文 王西玲 |
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| 作者单位： | In stitute of Neurosurgery of Chinese PLA，Xijing Hospital，Fourth Military Medical University，In stitute of Neurosurgery of Chinese PLA，Xijing Hospital，Fourth Military Medical University，In stitute of Neurosurgery of Chinese PLA，Xijing Hospital，Fourth Military Medical University，In stitute of Neurosurgery of Chinese PLA，Xijing Hospital，Fourth Military Medical University，In stitute of Neurosurgery of Chinese PLA，Xijing Hospital，Fourth Military Medical University，In stitute of Neurosurgery of Chinese PLA，Xijing Hospital，Fourth Military Medical University，In stitute of Neurosurgery of Chinese PLA，Xijing Hospital，Fourth Military Medical University Xi'an 710032，Shaanxi Province，China，Xi'an 710032，Shaanxi Province，China，Xi'an 710032，Shaanxi Province，China，Xi'an 710032，Shaanxi Province，China，Xi'an 710032，Shaanxi Province，China，Xi'an 710032，Shaanxi Province，China，Xi'an 710032，Shaanxi Province，China |
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| 摘 要： | INTRODUCTIONExtremityinjuriesarecommoninmodernfirearmwounds，constitut－ing５０％－６０％ofthetotal１－２]．Remoteeffecti．e．remoteorgansortissuesinjurywilloccurbesidesseriousandextensiveinjuryofthelocalinjurytractandsurroundingtissues，inwhichcerebralinjuryiscommon３－５]．PaststudiesshowedextremityinjuriescouldcausechangesinEEG，neuropeptide，andcerebralcirculation．Butnore－portonC－fosgeneexpressionwasfound．SUBJECTSANDMETHODSExperimentalanimalgrouping，establishmentofanim…
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Pathophysiological changes and mechanism of cerebral pathological after high-energy firearm wound in extremities of dogs |
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| Feng Yaping,Zhang Xiang,Fei Zhou,Wu Jingwen,Wu Yi,Liang Jingwen,Wang Xiling.In stitute of Neurosurgery of Chinese PLA,Xijing Hospital,Fourth Military Medical University,Xi'an ,Shaanxi Province,China.Pathophysiological changes and mechanism of cerebral pathological after high-energy firearm wound in extremities of dogs[J].Journal of Clinical Rehabilitative Tissue Engineering Research,2003(4). |
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| Authors: | Feng Yaping Zhang Xiang Fei Zhou Wu Jingwen Wu Yi Liang Jingwen Wang XilingIn stitute of Neurosurgery of Chinese PLA Xijing Hospital Fourth Military Medical University Xi'an Shaanxi Province China |
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| Institution: | Feng Yaping,Zhang Xiang,Fei Zhou,Wu Jingwen,Wu Yi,Liang Jingwen,Wang Xiling.In stitute of Neurosurgery of Chinese PLA,Xijing Hospital,Fourth Military Medical University,Xi'an 710032,Shaanxi Province,China |
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| Abstract: | AIM:To study the mechanism of cerebral pathological and pathophysiological cha nges after extremity gunshot wounds at molecular level.METHODS:M-193,5.56 mm bu llets were used to shoot the most plentiful part of the hind extremities of the dogs.C-fos gene expression in neurons of cerebral tissues of different time int ervals after gunshot in the subject and control groups were detected with immuno histochemistry.RESULTS:No C-fos gene expression was detected in the cerebral co rtical neurons in the control group.But in the subject group,C-fos expression i ncreased in the cerebral neurons 30 min after injury,reached the peak 6 hours(P< 0.05),and began to decrease 10 hours post-injury.CONCLUSION:After extremity gu nshot wound C-fos expression in neurons of distal parts is the early response o f the body to the injury,which might be caused by Leao's spreading depression(SD ),and correlated to extracellular transduction and cell apoptosis. |
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| Keywords: | pathology surgical brain injuries wounds and injuries |
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