| 安神类中成药中非法添加化学药成分检测方法研究 |
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| 引用本文： | 王怡君,孙苓苓,朱莹.安神类中成药中非法添加化学药成分检测方法研究[J].中国药事,2010,24(11):1074-1076. |
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| 作者姓名： | 王怡君 孙苓苓 朱莹 |
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| 作者单位： | 1. 辽宁省食品药品检验所,沈阳,110023
2. 沈阳市食品药品检验所 |
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| 基金项目： | 国家十一五课题子课题 |
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| 摘 要： | 目的建立对中成药中非法添加的10种苯二氮卓类化学成分的快速筛选方法。方法采用TLC法对安神类中成药中非法添加的地西泮、硝西泮、氯硝西泮、氯氮卓、奥沙西泮、马来酸咪哒唑仑、劳拉西泮、艾司唑仑、阿普唑仑、三唑仑进行快速筛选。结果建立了快速分离检验中成药中10种非法添加成分的测定方法,检测限低于0.1μg。结论该方法专属性强、灵敏度高,适用于安神类中成药中非法添加化学药成分的快速筛选。
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| 关 键 词： | TLC 安神类中成药 非法添加 快速筛查 |
Study of Screening for Illegal Adding of Chemical Compositions in TCM Calming the Nerves |
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| Wang Yijun,Sun Lingling,Zhu Ying.Study of Screening for Illegal Adding of Chemical Compositions in TCM Calming the Nerves[J].Chinese Pharmaceutical Affairs,2010,24(11):1074-1076. |
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| Authors: | Wang Yijun Sun Lingling Zhu Ying |
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| Institution: | (Liaoning Institute for Drug Control,Shengyang 110023;1Shenyang Institute for Drug Control) |
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| Abstract: | Objective To establish a determination method for simultaneous screening 10 chemical compositions of benzodiazepine in TCM.Methods TLC was used to screen diazepam,nitrazepam,clonazepam,clorazepate,oxazepam,midazolam maleate,lrazepam,estazolam,alprazolam and tiazolam in TCM calming the nerves.Results The method for simultaneous screening 10 chemical compositipn was established.The LOD of these substances were below 0.1μg.Conclusion The method is selective and sensitive to detect chemical composition in TCM calming the nerves. |
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| Keywords: | TLC |
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