石蒜碱的一些药理作用

石蒜碱能延长环己烯巴比妥钠、硫喷妥钠、水合氯醛等催眠剂原作用时间达2-4倍;能减少小鼠自发性活动,呈现明显的镇静作用;能增强延胡索乙素、吗啡等镇痛效力;能降低人工发热家兔体温;使乌拉坦麻醉兔尿量显著减少而呈抗利尿现象.通过大鼠条件反射及犬的呕吐反应证明,以3毫克与12毫克/公斤剂量水平的石蒜碱进行药理观察是适当的,前一剂量(3毫克/公斤)更具一定的实际意义.石蒜碱能抑制小鼠的呼吸代谢及肾脏琥珀酸脱氢酶的活力;降低兔心脏中ATP含量.大剂量抗坏血酸能增强石蒜碱的毒性.

SOME PHARMACOLOGICAL ACTIONS OF LYCORINE

When sodium evipan, sodium pentothal, chloral hydrate, or ethyl alcohol was used, lycorine (12 mg/kg I. P.) might prolong the sleeping time of mice by 2-4 times that of the control group. A very pronounced sedative action was observed when according to Richter's torsion method it was used intraperitoneally to mice with the dose level of 2-10 mg/kg. It lowered the temperature of normal rabbits and rabbits with fever induced by ty- phoid vaccine. It depressed the basal metabolic rate of mice and decreased the ATP content of the intact hearts of rabbits, both auricles and ventricles (3-12 mg/kg I. V.). Lycorine also inhibited the activity of the kidney succinic dehydrogenase when used intraperitoneally to the mice with the dose, level above 10 mg/kg. It is interesting to note that large amount of ascorbic acid (5-50 mg/mouse I.P.) might potentiate the toxicity of lycorine. This was contrary to what the literature had stated. From the experiments of conditioned reflex on rats and the emetic effect on dogs, it was found that 3 mg/kg of lycorine hypodermically injected was the appropriate dose level for practical significance.