| 雷公藤多苷分散片的制备工艺研究及质量控制 |
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| 引用本文： | 邓倩. 雷公藤多苷分散片的制备工艺研究及质量控制[J]. 中国实用医药, 2009, 4(9): 37-39 |
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| 作者姓名： | 邓倩 |
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| 作者单位： | 湖南省长沙市妇幼保健院,410007 |
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| 摘 要： | 目的制备雷公藤多苷分散片。方法筛选崩解剂、润湿剂、制粒方法、颗粒压片条件,并控制其质量。结果崩解剂的最佳比例为MCC：L-HPC=11：3;制粒时选用水为其润湿剂,润湿剂用量为药粉重量的80%（ml/g）;20目筛制粒,30目筛整粒。所制备的分散片在3min内崩解完全,含量均匀,稳定性好,符合分散片的各项指标。结论本品达到分散片的要求,制剂稳定。
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| 关 键 词： | 分散片 雷公藤多苷 制备工艺 高效液相色谱法 雷公藤内酯甲 |
Preparation and quality investigation of tripterygium glycosides dispersible tablets |
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| DENG Qian. Preparation and quality investigation of tripterygium glycosides dispersible tablets[J]. China Practical Medical, 2009, 4(9): 37-39 |
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| Authors: | DENG Qian |
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| Affiliation: | DENG Qian.( Changsha Maternity and Child Health Care Hospital, Changsha, Hunan 410007, China) |
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| Abstract: | Objective To prepare Tripterygium Glycosides dispersible tablets. Methods tilt disintegrating agent, wetting agent, granulate method, clip condition of Tripterygium Glycosides dispersible tablets, and control its quality. Results The optimum proportion of disintegrating agent was MCC ： L-HPC = 11 ： 3, moistening agent was water, and its weight as same as 80% weight of medicine powder（ ml/g）. The screen mesh was 20 meshes of granulate, and it was 30 meshes of mend pill. The dispersible tablets all disaggregated in 3 minutes and content well-distributed, stability was well, meeting the requirements of all the indexes of dispersible tablets. Conclusion It has met all the requirements of disapersible tablets. |
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| Keywords: | Dispersible tablets Tripterygium Glycosides Preparation technology High-performance liquid chromatography Wilforlide |
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