大黄浓缩干燥过程中活性成分的稳定性

目的:研究大黄提取后浓缩干燥过程中各活性成分的稳定性.方法:以大黄提取液中各活性成分为研究对象,在浓缩干燥过程中不同时间点取样,HPLC分别对其测定,检测相对含量变化趋势.结果:在70℃受热过程中,各活性成分相对含量在浓缩ih后降解程度较大,浓缩2h与1h后相比减少不明显,浓缩3h后含量则显著降低;70℃减压干燥过程中,各活性成分含量在干燥2h后降解程度较大,干燥3h与干燥2h相比变化不大,总趋势相对较稳定,干燥过程对各活性成分含量影响较小.番泻苷D受热易分解.结论:大黄提取液在70℃减压浓缩干燥过程中,浓缩时间宜控制在2h之内,各成分在干燥3h过程内稳定.

Stability of Active Ingredients from Rheum officinale in Concentration and Drying Process

Objective:To study on stability of active ingredients from Rheum officinale in concentration and drying process.Method:Taking active ingredients from extraction fluid of R.officinale as studying target,samples were taken at different time points in concentration and drying progress,change trends of relative content was determined by HPLC.Result:The relative content of active ingredients were degraded greater degree after concentrated 1 h in process of heating at 70 ℃,its reduction is not obvious after concentrated 2 h by comparing with 1 h,but after concentrated for 3 h,the relative content reduced significantly;At 70 ℃ vacuum drying process,active ingredients were in large degree of degradation after drying 2 h,the change of content was small after drying 3 h by comparing with 2 h,general trend was relative stable,the content of active ingredients was less affected in drying process.Sennoside D decomposed easily in heating.Conclusion:During in process of concentration and drying at 70 ℃ vacuum for extraction fluid from R.officinale,concentration time should be controlled within 2 h,components were stable in drying time for 3 h.